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Nisha Nagarkatti-Gude, J Peter Campbell, Eric B Suhler, James T Rosenbaum, Phoebe Lin; Autofluorescence Characteristics in Multifocal Choroiditis. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6189.
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Analysis of wide-field fundus autofluorescence (FAF) may yield information on the changes in structure and/or function of the retinal pigment epithelium (RPE). The purpose of this retrospective, observational study was to evaluate wide-field FAF characteristics associated with multifocal choroiditis (MFC).
This study examined 20 patients diagnosed with MFC. Best-corrected Snellen visual acuity, complete slit lamp exam and dilated fundoscopic exam, Optos fundus photography, optical coherence tomography (OCT), and multiple wide-field FAF images were completed on each patient. If indicated, fluorescein angiography and indocyanine green angiography were performed. Demographic information, treatment modalities, and laboratory evaluation of bloodwork were used for correlative studies. Integrative analysis was performed not only to compare FAF patterns to those visualized on other imaging modalities but also to examine how these patterns evolve through the course of this condition.
Of 20 patients with MFC, 17 were female, 3 were male, and ages ranged from 14-68 with an average of 41.5. 2 patients were excluded for lack of wide-field imaging. 66% of patients with MFC had lesions on FAF that were not present on Optos fundus pictures or described on clinical exam. During follow up, many patients developed new chorioretinal changes documented on fundus photography at sites that were earlier noted only on FAF. FAF images also enabled a more objective examination of areas that could not be evaluated by OCT.
Our results suggest that in MFC, wide-field FAF imaging may provide information on changes to the outer retina/RPE that are not seen on regular fundus pictures or exam. Moreover, wide-field imaging allows better characterization of these lesions in the posterior pole and periphery in a non-invasive manner.
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