June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
The Epidemiology of Dry Eye Disease in South Korea: Old age may be not a Major Risk factor in Dry Eye Disease.
Author Affiliations & Notes
  • Yujeong Kim
    Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
    Seoul National University Hospital Clinical Research Institute, Seoul, Korea (the Republic of)
  • DongHyun Kim
    Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
    Seoul National University Hospital Clinical Research Institute, Seoul, Korea (the Republic of)
  • Kyung Chul Yoon
    Ophthalmology, Chonnam National University Medical School, Gwangju, Korea (the Republic of)
  • Mee Kum Kim
    Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
    Seoul National University Hospital Clinical Research Institute, Seoul, Korea (the Republic of)
  • Won Ryang Wee
    Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
    Seoul National University Hospital Clinical Research Institute, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships Yujeong Kim, None; DongHyun Kim, None; Kyung Chul Yoon, None; Mee Kum Kim, None; Won Ryang Wee, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 6192. doi:
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      Yujeong Kim, DongHyun Kim, Kyung Chul Yoon, Mee Kum Kim, Won Ryang Wee; The Epidemiology of Dry Eye Disease in South Korea: Old age may be not a Major Risk factor in Dry Eye Disease.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6192.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the relation of old age and the other risk factors with dry eye disease (DED) in South Korea.

 
Methods
 

Design: Population based cross-sectional study<br /> We included 18,349 subjects between the ages of 19 and 97 year, from the 5th Korea National Health and Nutrition Examination Survey (KNHANES V) between 2010 and 2012<br /> DED was defined as previously diagnosed by an ophthalmologist or the presence of symptoms. Sociodemographic, medical, lifestyle, and ocular factors were assessed as potential risk factors for DED using univariate and multivariate logistic regression analysis.<br /> To assess the effect of age on DED, age-adjusted univariate odds ratio (OR) was compared with unadjusted OR regarding each variable and correlation analysis between DED prevalence and age was performed. DED in postmenopausal women according to hormone replacement therapy (HRT) were also investigated to evaluate the effect of sex hormone on DED.

 
Results
 

Significant risk factors of DED were female sex (DED symptom/diagnosis OR=2.00/2.35, all p<0.0001), dyslipidemia [1.27/1.40], rheumatoid arthritis [1.24/1.47], depression [1.30/1.21], chronic renal failure [1.87/2.95], thyroid disease [1.47/1.65], sleeping < 7 hours [1.22/1.28], high perceived stress [1.27/1.18], poor subjective health awareness (good subjective health awareness OR=0.60/0.68, all p<0.0001), and previous ocular surgery [1.91/2.07, all p<0.0001] in multivariate logistic regression (all p<0.05). The OR of the elderly group (age≥65 year) for DED symptoms and diagnosis were 1.15/1.07[symtoms/diagnosis] (unadjusted univariate logictic regression, p>0.05)0.78/0.64(multivariate logistic regression, p<0.05), compared with the young group (age 19-40). In addition, the prevalence of DED symptoms and diagnosis did not increase with age (Pearson correlation, R2=0.0023, p 0.6937/R2=0.0011, p=0.7855). Postmenopausal women who had received HRT were more likely to have DED diagnosis than patients with no HRT history (multivariate OR=1.68, p=0.0001)

 
Conclusions
 

Age may not be a risk factor in DED in Korean population, while DED may be significantly associated by female sex, previous ocular surgery and poor subjective health awareness.

 
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