June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Glaucoma Structural and Functional Progression in American and Korean Cohorts
Author Affiliations & Notes
  • Tigran Kostanyan
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Kyung Rim Sung
    Asan Medical Center, Department of Ophthalmology, University of Ulsan College of Medicine, Seoul, Korea (the Republic of)
  • Joel S Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA
  • Yun Ling
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
  • Richard Anthony Bilonick
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
  • Hiroshi Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA
  • Larry Kagemann
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA
  • Michelle Gabriele Sandrian
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA
  • Jin Young Lee
    Asan Medical Center, Department of Ophthalmology, University of Ulsan College of Medicine, Seoul, Korea (the Republic of)
  • Gadi Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Footnotes
    Commercial Relationships Tigran Kostanyan, None; Kyung Rim Sung, None; Joel Schuman, Zeiss (P); Yun Ling, None; Richard Bilonick, None; Hiroshi Ishikawa, None; Larry Kagemann, None; Michelle Sandrian, None; Jin Young Lee, None; Gadi Wollstein, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 621. doi:
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      Tigran Kostanyan, Kyung Rim Sung, Joel S Schuman, Yun Ling, Richard Anthony Bilonick, Hiroshi Ishikawa, Larry Kagemann, Michelle Gabriele Sandrian, Jin Young Lee, Gadi Wollstein; Glaucoma Structural and Functional Progression in American and Korean Cohorts. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):621.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Numerous studies on glaucomatous structural and functional progression have been published but it is unclear whether these results can be generalized given different geographic locations, ethnicities and disease types. In this study, we compare the rate of glaucomatous progression in American and Korean cohorts.

 
Methods
 

Glaucoma suspect and glaucomatous eyes with ≥4 reliable visual fields (VF; Humphrey Field Analyzer; Zeiss, Dublin, CA) and optical coherence tomography (OCT; Cirrus HD-OCT, Zeiss) were included in the study. VF mean deviation (MD), visual field index (VFI), peripapillary retinal nerve fiber layer (RNFL) thickness, and cup to disc (C/D) ratio were used in linear mixed effect analysis while accounting for baseline age for estimation of progression rate.

 
Results
 

The American cohort included 103 glaucoma and 73 glaucoma suspect eyes and the Korean cohort included 100 and 103 eyes, respectively. The overall follow-up period was 36.2±9.2 months. The majority (96.6%) of the American glaucoma eyes were categorized as high-tension glaucoma, whereas 85.7% of the Korea glaucoma eyes were diagnosed as low-tension glaucoma. At baseline, the Korean cohort was statistically significantly younger than the American (56.8 vs. 61.8 yrs.) with thicker RNFL (81.3 vs. 77.4 μm) and a larger cupping (0.7 vs. 0.6). There was no statistically significant difference in baseline MD between cohorts (-2.5 vs. -2.8 dB). No significant difference was detected in the rate of change between the cohorts for any of the parameters in the glaucoma suspect group. However, Korean glaucoma eyes showed significantly steeper progression slopes by average and nasal RNFL thickness and significantly shallower slope for average C/D ratio (Table).

 
Conclusions
 

Patient ethnicity and disease type should be considered when comparing glaucoma structural progression studies.  

 
Table. Progression rate in glaucomatous eyes. Parameters are reported as mean and 95% confidence intervals (linear mixed effect modeling).<br /> <br />
 
Table. Progression rate in glaucomatous eyes. Parameters are reported as mean and 95% confidence intervals (linear mixed effect modeling).<br /> <br />

 
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