June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Comparison of the topographic correlation with retinal nerve fiber layer defect between beta-zone and gamma-zone parapapillary atrophy
Author Affiliations & Notes
  • Eun Hye Jung
    Department of ophthalmology, Seoul National University Bundang Hospital, Seoul, Korea (the Republic of)
  • Tae-Woo Kim
    Department of ophthalmology, Seoul National University Bundang Hospital, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships Eun Hye Jung, None; Tae-Woo Kim, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 647. doi:
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    • Get Citation

      Eun Hye Jung, Tae-Woo Kim; Comparison of the topographic correlation with retinal nerve fiber layer defect between beta-zone and gamma-zone parapapillary atrophy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):647.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

It has long been recognized that beta-zone parapapillary atrophy (PPA) is topographically correlated with retinal nerve fiber layer defect. Recently, beta-zone PPA has been further divided into beta-zone and gamma-zone. This study was conducted to investigate whether the topographic correlation with retinal nerve fiber layer (RNFL) defect differs between beta-zone and gamma-zone PPA.

 
Methods
 

Color and red-free fundus photographs of primary open angle glaucoma (POAG) patients who had beta-zone or gamma-zone PPA, and a single localized RNFL defect were reviewed. The PPA was classified according to the presence or absence of the Bruch’s membrane on the PPA bed in the spectral domain optical coherence tomography image. Angular location of the RNFL defect and the point of maximum radial extent (PMRE) of PPA were measured with the fovea-disc axis set at 0 degree. Angular extent of RNFL defect and PPA were also measured.

 
Results
 

Of 464 eyes, 122 (26.3%) POAG eyes had single localized RNFL defect together with beta-zone (group A, n=53) or gamma-zone PPA (group B, n=27). There was no significant difference in the angular location of PMRE (P = 0.917) and extent of RNFL defect (P = 0.146) between the 2 groups. However, the angular distance between the RNFL defect and PMRE was significantly greater in group B than in group A ( 36.51 ± 21.13° vs 66.96 ± 24.13°, P<0.001).

 
Conclusions
 

The RNFL defect was observed close to the PMRE in eyes with beta-zone PPA, but not in eyes with gamma-zone PPA. This finding supports that the beta-zone and gamma-zone PPA have different pathogenic influence regarding glaucomatous optic nerve damage.  

 
Figure. Color and red-free fundus photographs of eyes with beta-zone (A,B) and gamma-zone (C,D) parapapillary atrophy (PPA). B, The retinal nerve fiber layer defect (RNFLD) is seen at the location of maximum PPA width. D, The RNFLD is seen far from the maximum PPA width.
 
Figure. Color and red-free fundus photographs of eyes with beta-zone (A,B) and gamma-zone (C,D) parapapillary atrophy (PPA). B, The retinal nerve fiber layer defect (RNFLD) is seen at the location of maximum PPA width. D, The RNFLD is seen far from the maximum PPA width.

 
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