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Itaru Kimura, Kazunori Tamaki, Tomoko Yoshikawa, Yutaka Imamura, Satoshi Watanabe, Yugo Nakazawa, Nobuyuki Ebihara; The investigation of changes in subfoveal choroidal thickness and sensitivity of visual field in highly myopic glaucoma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):648.
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© ARVO (1962-2015); The Authors (2016-present)
To measure the changes of subfoveal choroidal thickness and sensitivity of visual field in POAG patients with high myopia, and to investigate the choroidal thickness changes and refraction error, and MD values changes, with the degree of peripapillary atrophy(PPA).
64 eyes from 40 patients(aveage age 56.1 years old) diagnosed as POAG including preperimetric glaucoma with spherical equivalent refractive error under -6 diopters were studied. They were classified into 2 groups, one had not the disc with whole surrounding PPA (L-group; 39 eyes) and the group which had the disc with whole surrounding PPA (S-group; 25 eyes). They were also classified into 2 groups, one had MD values change equql to or less than -0.72dB/year (A-group), and the group with MD values change more than -0.72dB/year (B-group). Subfoveal choroid was imaged with Cirrus HD-OCT (Carl Zeiss Meditec) and its thickness was measured. The correlation were investigated between choroidal thickness and MD value of Humphrey SITA standerd(30-2), and the correlation were compared between L and S-group, and A and B-group.
In S-group, the spherical equivqlent (SE) and the decrease of subfoveal choroidal thickness were -8.90±3.19D, -0.77±1.3um/month in A-group, and -9.00±3.71D, -0.80±1.2um/month in B-group, respectively. There was no significant changes between A and B-group. In L-group the SE and the decrease of subfoveal choroidal thickness were -7.74±1.42D, -0.25±1.3um/month in A-group, and -10.33±3.10D, -0.049±1.1um/month in B-group. There were significant changes in SE between A and B-group (P=0.0044). The decrease of subfoveal choroidal thickness of A-group was more than B-group though this was not significant (p>0.05).
It was shown that the faster the speed of decrease in sensitivity of visual field, the less degree of myopia, the more decrease tendency in subfoveal choroidal thickness in patients who have not whole surrounding PPA, though there are no significant changes in degree of myopia or decrease of subfoveal choroidal thickness between fast and slow groups in decrease of visual field sensitivity in patients who have whole surrounding PPA in highly myopic glaucoma.
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