June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Family history, near work, outdoor, height and myopia in 3 year old Asian children: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) Study
Author Affiliations & Notes
  • Seang-Mei Saw
    Singapore Eye Research Institute, Singapore, Singapore
    National University of Singapore and National Health Systems, Singapore, Singapore
  • Sharon Chua
    National University of Singapore and National Health Systems, Singapore, Singapore
  • Cheryl Ngo
    National University of Singapore and National Health Systems, Singapore, Singapore
  • Chuen-Seng Tan
    National University of Singapore and National Health Systems, Singapore, Singapore
  • Yung-Seng Lee
    National University of Singapore and National Health Systems, Singapore, Singapore
  • Shirong Cai
    National University of Singapore and National Health Systems, Singapore, Singapore
  • Peter Gluckman
    National University of Singapore and National Health Systems, Singapore, Singapore
    Liggins Institute, University of Auckland, Auckland, New Zealand
  • Yap Seng Chong
    National University of Singapore and National Health Systems, Singapore, Singapore
    Singapore Institute of Clinical Sciences, Singapore, Singapore
  • Mohammad Kamran Ikram
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS GMS, National University of Singapore, Singapore, Singapore
  • Tien Yin Wong
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS GMS, National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships Seang-Mei Saw, None; Sharon Chua, None; Cheryl Ngo, None; Chuen-Seng Tan, None; Yung-Seng Lee, None; Shirong Cai, None; Peter Gluckman, None; Yap Seng Chong, None; Mohammad Ikram, None; Tien Wong, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 903. doi:
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      Seang-Mei Saw, Sharon Chua, Cheryl Ngo, Chuen-Seng Tan, Yung-Seng Lee, Shirong Cai, Peter Gluckman, Yap Seng Chong, Mohammad Kamran Ikram, Tien Yin Wong, ; Family history, near work, outdoor, height and myopia in 3 year old Asian children: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) Study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):903.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To investigate the associations of parental myopia, early life exposure to near work and outdoor, as well as anthropometric measures with early-onset myopia in very young Asian children.

Methods: Methods: We conducted a birth cohort which recruited pregnant women and their offsprings at two major maternity units in Singapore. At 3 years of age, cycloplegic autorefraction and axial length (AL) were obtained from participating children (n=572). Myopia was defined as spherical equivalent (SE) of ≤ -0.50 diopters (D). Parents completed detailed questionnaires of near work, outdoor activities and parental myopia at the child’s two year visit. Taller children at birth, 12, 24 and 36 months, were found to have longer AL at 3 years.

Results: Results: In multivariable regression models adjusted for gender, race and maternal education, children with at least one myopic parent were more likely to have a more myopic SE (b= -0.29D; 95% CI: -0.49 to -0.09D; p<0.01), longer AL (b = 0.15mm; 95% CI: 0.03 to 0.27mm; p=0.02) and higher odds of myopia (OR= 3.31; 95% CI: 1.09 to 10.09; p=0.04). Neither near work nor outdoor activity were associated with SE, AL or myopia. Taller children were found to have longer AL at birth,12, 24 and 36 months, but there were no associations with SE or myopia.

Conclusions: Parental history of myopia was associated with early-onset myopia in young 3- year old Asian children. In contrast, neither near work nor outdoor activity were associated with early-onset myopia. Child’s height at regular intervals from birth to 3 years was related to AL, but not SE. These data suggest that early onset myopia is more likely due to genetic rather than environmental factors, while height at several age points predict AL at 3 years.

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