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Anand Vinekar, Amit Zope, Shwetha Mangalesh, Chaitra Jayadev, Sivakumar Munusamy, Vasudha Kemmanu, Padmamalini Mahendradas, Kavitha Avadhani, Noel Bauer, K Bhujang Shetty, ; Correlating Foveal Spectral Domain Optical Coherence Tomography With Visual Acuity In Premature Infants With And Without Retinopathy Of Prematurity. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):951.
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© ARVO (1962-2015); The Authors (2016-present)
To prospectively report foveal morphology on spectral domain optical coherence tomography (SD-OCT) in premature infants with and without retinopathy of prematurity (ROP) in their first corrected year of life and to correlate this with visual acuity
Fifty eyes (25 premature infants) who completed photo documented ROP screening were subjected to hand-held SD-OCT (Bioptigen,NC,USA) imaging in the office along with visual acuity assessment using Teller Acuity Cards at 3,6,9 and 12 months of corrected ages respectively. Best rectangular scans representing the foveal center were selected by masked pediatric retinal specialists. Images were evaluated for individual layers of the retina, inner retinal layer fusion or immaturity, foveal dip and foveal tent.Factorial ANOVA and univariate analysis of variance tests were performed.
The overall mean visual acuity improved with increasing study intervals (1.75, 1.50, 1.28 and 1.17 logMar at 3,6,9, and 12 months respectively (P < 0.0001).Morphological features on SD-OCT that positively correlated with visual acuity included:1) inner retinal layer fusion (41.3%, 54.2%, 70%, 72%, P=0.006) and presence of 2)outer segment-retinal pigment epithelium (OS-RPE)(4.3%, 47.9%, 72.0%, 76.0%, P < 0.0001) 3)external limiting membrane(10.9%, 52.1%, 74.%, 84%, P < 0.0001) 4)foveal tent (8.7%, 52.1%, 76%, 86%, P < 0.0001) assessed at 3,6,9,and 12 months respectively.Subgroup analysis correlating SD-OCT layers with the presence (n=32) and absence (n=18) of ROP showed that in the group without ROP there was a significant difference between those with and without these layers,with the former showing better acuity through the study period.However, in the group that had ROP, there was no significant different between those with and without these layers (Fig. 1 and 2)
This is the first prospective study correlating visual acuity with SD-OCT morphology in premature infants in the first year of life.Visual acuity improves as the infant grows from 3 to 12 months.Four morphological features on SD-OCT correlated with better vision in the group without ROP.In the ROP cohort, although vision improved with age, SD-OCT features seemed to play a less influential role in this process
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