June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Correlating Foveal Spectral Domain Optical Coherence Tomography With Visual Acuity In Premature Infants With And Without Retinopathy Of Prematurity
Author Affiliations & Notes
  • Anand Vinekar
    Pediatric Retina, Narayana Nethralaya, Bangalore, India
  • Amit Zope
    Pediatric Retina, Narayana Nethralaya, Bangalore, India
  • Shwetha Mangalesh
    Pediatric Retina, Narayana Nethralaya, Bangalore, India
  • Chaitra Jayadev
    Pediatric Retina, Narayana Nethralaya, Bangalore, India
  • Sivakumar Munusamy
    Pediatric Retina, Narayana Nethralaya, Bangalore, India
  • Vasudha Kemmanu
    Pediatric Ophthalmology, Narayana Nethralaya, Bangalore, India
  • Padmamalini Mahendradas
    Uvea and Ocular Inflammation, Narayana Nethralaya, Bangalore, India
  • Kavitha Avadhani
    Uvea and Ocular Inflammation, Narayana Nethralaya, Bangalore, India
  • Noel Bauer
    Ophthalmology, Maastricht University, Maastricht, Netherlands
  • K Bhujang Shetty
    Ophthalmology, Narayana Nethralaya, Bangalore, India
  • Footnotes
    Commercial Relationships Anand Vinekar, None; Amit Zope, None; Shwetha Mangalesh, None; Chaitra Jayadev, None; Sivakumar Munusamy, None; Vasudha Kemmanu, None; Padmamalini Mahendradas, None; Kavitha Avadhani, None; Noel Bauer, None; K Bhujang Shetty, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 951. doi:
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      Anand Vinekar, Amit Zope, Shwetha Mangalesh, Chaitra Jayadev, Sivakumar Munusamy, Vasudha Kemmanu, Padmamalini Mahendradas, Kavitha Avadhani, Noel Bauer, K Bhujang Shetty, ; Correlating Foveal Spectral Domain Optical Coherence Tomography With Visual Acuity In Premature Infants With And Without Retinopathy Of Prematurity. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):951.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To prospectively report foveal morphology on spectral domain optical coherence tomography (SD-OCT) in premature infants with and without retinopathy of prematurity (ROP) in their first corrected year of life and to correlate this with visual acuity

 
Methods
 

Fifty eyes (25 premature infants) who completed photo documented ROP screening were subjected to hand-held SD-OCT (Bioptigen,NC,USA) imaging in the office along with visual acuity assessment using Teller Acuity Cards at 3,6,9 and 12 months of corrected ages respectively. Best rectangular scans representing the foveal center were selected by masked pediatric retinal specialists. Images were evaluated for individual layers of the retina, inner retinal layer fusion or immaturity, foveal dip and foveal tent.Factorial ANOVA and univariate analysis of variance tests were performed.

 
Results
 

The overall mean visual acuity improved with increasing study intervals (1.75, 1.50, 1.28 and 1.17 logMar at 3,6,9, and 12 months respectively (P < 0.0001).Morphological features on SD-OCT that positively correlated with visual acuity included:1) inner retinal layer fusion (41.3%, 54.2%, 70%, 72%, P=0.006) and presence of 2)outer segment-retinal pigment epithelium (OS-RPE)(4.3%, 47.9%, 72.0%, 76.0%, P < 0.0001) 3)external limiting membrane(10.9%, 52.1%, 74.%, 84%, P < 0.0001) 4)foveal tent (8.7%, 52.1%, 76%, 86%, P < 0.0001) assessed at 3,6,9,and 12 months respectively.Subgroup analysis correlating SD-OCT layers with the presence (n=32) and absence (n=18) of ROP showed that in the group without ROP there was a significant difference between those with and without these layers,with the former showing better acuity through the study period.However, in the group that had ROP, there was no significant different between those with and without these layers (Fig. 1 and 2)

 
Conclusions
 

This is the first prospective study correlating visual acuity with SD-OCT morphology in premature infants in the first year of life.Visual acuity improves as the infant grows from 3 to 12 months.Four morphological features on SD-OCT correlated with better vision in the group without ROP.In the ROP cohort, although vision improved with age, SD-OCT features seemed to play a less influential role in this process  

 
Inner retinal maturity and ELM vs visual acuity with and without ROP
 
Inner retinal maturity and ELM vs visual acuity with and without ROP
 
 
Foveal tent and OS-RPE vs visual acuity with and without ROP
 
Foveal tent and OS-RPE vs visual acuity with and without ROP

 
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