March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Diagnostic performance of the Moorfields Motion Displacement Test for glaucoma
Author Affiliations & Notes
  • Ee Lin Ong
    Singapore National Eye Centre, Singapore, Singapore
  • Yingfeng Zheng
    Singapore Eye Research Institute,
    Singapore National Eye Centre, Singapore, Singapore
  • Gay M. Verdon-Roe
    Glaucoma Research Unit, Moorfields Eye Hospital, London, United Kingdom
  • David F. Garway-Heath
    Institute of Ophthalmology, University College London, London, United Kingdom
  • Ciara Bergin
    Institute of Ophthalmology, University College London, London, United Kingdom
  • Tien Y. Wong
    Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore
  • Tin Aung
    Glaucoma,
    Singapore National Eye Centre, Singapore, Singapore
  • Alicia How
    Singapore National Eye Centre, Singapore, Singapore
  • Footnotes
    Commercial Relationships  Ee Lin Ong, None; Yingfeng Zheng, None; Gay M. Verdon-Roe, Moorfields MDT (P), Pfizer (F); David F. Garway-Heath, Carl Zeiss Meditec (F, R), Heidelberg Engineering (F), Moorfields MDT (P); Ciara Bergin, Moorfields MDT (P); Tien Y. Wong, None; Tin Aung, None; Alicia How, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 180. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ee Lin Ong, Yingfeng Zheng, Gay M. Verdon-Roe, David F. Garway-Heath, Ciara Bergin, Tien Y. Wong, Tin Aung, Alicia How; Diagnostic performance of the Moorfields Motion Displacement Test for glaucoma. Invest. Ophthalmol. Vis. Sci. 2012;53(14):180.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : The Moorfields Motion Displacement Test (MMDT, ESTA Version 1, London, UK) is a 31-point suprathreshold test for visual field assessment using moving line stimuli displayed on a standard laptop computer. Our purpose was to evaluate the diagnostic performance of the MMDT for discriminating between healthy eyes and eyes with glaucoma.

Methods: : This was an observational case-control study of glaucoma subjects and normal controls. All participants underwent a standardized ophthalmological examination including visual field testing, the MMDT and Heidelberg Retina Tomography (HRT, Heidelberg Engineering, Heidelberg, Germany) scanning of the optic disc. Glaucoma was defined on clinical examination as loss of neuroretinal rim with cup:disc ratio of ≥0.7 and a HRT Moorfields Regression Analysis (HRA) result of "outside normal limits" in any sector with adequate image quality. Normal eyes were defined as having an intraocular pressure of ≤21mmHg with cup-disc ratio <0.6 and HRA analysis of "within normal limits". The Pandora response version of Enhanced Standard Threshold Algorithm (ESTA) was used for the MMDT in this study. The MMDT was performed without optical correction. Subjects with a false positive response of ≥15% were excluded. In the MMDT, a measure of probability of true damage (PTD, 0-100%) was derived for each location. Global PTD was calculated as a sum of individual PTD values for all 31 locations expressed as a quotient of 100. An abnormal result was defined as a global PTD ≥ 2.0. Data analysis using area under the curve (AUC) receiver operating characteristic (ROC), sensitivity, and specificity was then performed to evaluate the diagnostic performance of the MMDT. Only right eyes were used for analysis.

Results: : A total of 78 subjects with glaucoma (mean age: 66.6+/-13.1, male gender: 55.1%) and 363 healthy subjects (mean age: 55.6+/-9.5, male gender: 35.5%) were analyzed. The AUC was 0.920 (95% confidence interval: 0.883, 0.958) for global PTD in identifying eyes with glaucoma. At 85% specificity, the Moorfields MDT demonstrated a sensitivity of 88.5%. This decreased to 73.1% at 95% specificity. At the global PTD cut off point value of 2.0, the sensitivity was 85.9% and the specificity was 92.6%.

Conclusions: : The suprathreshold MMDT showed good diagnostic performance for glaucoma diagnosis when glaucoma was defined by a structural criterion.

Keywords: visual fields • perimetry • optic disc 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×