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Emanuel M. BOGADO, Maria Angeles Sebastian, Sergio Martin, Alicia Gomez, Ana Puntí, Maria Eleonora Ayala, Sebastian Banegas, Antonio Morilla-Grasa, Alfonso Anton-Lopez; Assessment of the diagnostic capabilities of Moorfields Motion Displacement Test (MMDT) for the detection of glaucoma suspects and glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2012;53(14):197.
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To assess the sensitivity, specificty and Receiver Operating Characteristic Curves of MMDT for the detection of glaucoma patients and glaucoma suspects.
Eighty eight eyes of 88 subjects were included in this cross-sectional study. All underwent a complete ophthalmic examination including 24-2 SITA Standard Humphrey visual fields, optic disc photographs and MMDT field with Enhanced Supra-threshold Algorithm (ESTA). Forty three were normal subjects with normal fields and discs, 22 were glaucoma suspects with abnormal fields or discs, and 23 were glaucoma patients with abnormal fields and discs. The number of missed points (MP) and mean probability of true damage (PTD) were calculated from MMDT results. Sensitivity at 90% specificity and the area under the Receiver Operating Characteristic Curves (AROC) were calculated for missed points (MP) and for the PTD.
The number of MP in MMDT was significantly higher (p<0.01, ANOVA) in glaucoma eyes (12.6 +- 11.3) than in glaucoma suspects (3.4 +- 7.1) or normal subjects (2.0 +- 5.4). PTD was also significantly higher (p<0.01 ANOVA) in glaucoma eyes (34.3 +- 34-3) than in glaucoma suspects (8.7 +- 21.6) or normal subjects (4.0 +- 13.2). The sensitivity at 90% specificity was 61% for both MP and PTD when identifying glaucoma patients from normal subjects. The AROC were 0.776 and 0.783 for MP and PTD, respectively, when classifying between glaucoma eyes and normal eyes. The AROC were 0.698 and 0.705 for MP and PTD, respectively, when classifying between eyes with glauoma or suspicion of the disease and normal eyes.
MMDT parameters were significantly different in glaucoma eyes than in normal subjects and identified glaucoma cases with an AROC of 0.776-0.783.
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