March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Impact Of The Preoperative Duration Of Stromal Edema In Bullous Keratopathy On Early Visual Acuity After Endothelial Keratoplasty
Author Affiliations & Notes
  • Yukiko Morita
    Department of Ophthalmology, Yamaguchi University Sch of Med, Ube, Japan
  • Naoyuki Morishige
    Department of Ophthalmology, Yamaguchi University Sch of Med, Ube, Japan
  • Tai-ichiro Chikama
    Department of Ophthalmology, Yamaguchi University Sch of Med, Ube, Japan
  • Naoyuki Yamada
    Department of Ophthalmology, Yamaguchi University Sch of Med, Ube, Japan
  • Norihisa Takahashi
    Department of Ophthalmology, Yamaguchi University Sch of Med, Ube, Japan
  • Teruo Nishida
    Department of Ophthalmology, Yamaguchi University Sch of Med, Ube, Japan
  • Koh-Hei Sonoda
    Department of Ophthalmology, Yamaguchi University Sch of Med, Ube, Japan
  • Footnotes
    Commercial Relationships  Yukiko Morita, None; Naoyuki Morishige, None; Tai-ichiro Chikama, None; Naoyuki Yamada, None; Norihisa Takahashi, None; Teruo Nishida, None; Koh-Hei Sonoda, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 46. doi:
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      Yukiko Morita, Naoyuki Morishige, Tai-ichiro Chikama, Naoyuki Yamada, Norihisa Takahashi, Teruo Nishida, Koh-Hei Sonoda; Impact Of The Preoperative Duration Of Stromal Edema In Bullous Keratopathy On Early Visual Acuity After Endothelial Keratoplasty. Invest. Ophthalmol. Vis. Sci. 2012;53(14):46.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To clarify the relation between visual acuity after Descemet stripping automated endothelial keratoplasty (DSAEK) and the preoperative duration of stromal edema.

Methods: : Twenty-eight subjects who underwent DSAEK were divided into two groups on the basis of a preoperative duration of stromal edema of <12 months (group A, n = 22) or ≥12 months (group B, n = 6). None of the subjects had postoperative conditions that might have affected the visual outcome of surgery. Best corrected visual acuity (BCVA) was measured at various times after surgery, and the morphology of the anterior cornea was evaluated by in vivo laser confocal microscopy.

Results: : BCVA in group A ranged from 20/50 to 20/16 at 3 months and from 20/66 to 20/16 at 6 months after surgery, with the maximal values being 20/40 to 20/13. BCVA in group B ranged from 20/66 to 20/40 at 3 and 6 months, with maximal values of 20/66 to 20/33. The structure of the anterior cornea was normal in subjects of group A but was abnormal, with fibroblastic cells apparent in the anterior stroma, in subjects of group B.

Conclusions: : Patients with a preoperative duration of stromal edema of ≥12 months had pathological changes in the corneal stroma that may have adversely affected visual acuity after DSAEK. Given that stromal edema including that associated with bullous keratopathy has been proposed to be a progressive condition, DSAEK may be most effective when performed early after the onset of edema, before the occurrence of pathological changes in the stroma.

Keywords: cornea: endothelium 
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