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Xuan Xiao, Wen Fan, Yanning Yang; A Retrospective Analysis of Causes of Corneal Perforation in the Central China Region. Invest. Ophthalmol. Vis. Sci. 2012;53(14):75.
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We set out to conduct a retrospective analysis of the primary eye conditions that lead to corneal perforation from cases collected in the central China region. The purpose of the study is to provide some basic knowledge for the prevention and treatment of the disease.
The data of inpatients diagnosed with corneal perforation in Renmin Hospital of Wuhan University from January 2006 to December 2010 were collected, and the primary causes for corneal perforation were analyzed.
348 eyes of inpatients with corneal perforation were included in this study, among which corneal perforation occurred in both eyes in 11 cases. Ocular trauma (56.3%) was the most common cause of corneal perforation, followed by infectious corneal diseases (37.6%). In cases of ocular trauma, the percentage of corneal penetrating injury was highest (63.3%), followed by explosion injury (25.5%), thermal burn (9.2%), chemical injury (2%). In cases of infectious corneal diseases, the most common pathogens were fungi(37.4%), followed by unknown keratitis (26.0%), bacteria (19.8%) and herpes simplex virus (16%). Repetitive corneal perforations occurred in 5 eyes, of which the primary diseases were HSK (2 cases), Mooren’s ulcer (2 cases) and alkali burn (1 case). Binocular corneal perforation occurred in 11 patients, among which the primary causes were explosion injury (7 case) and alkali burn (4 case).
Ocular trauma and infectious corneal diseases are the two most common primary eye conditions that lead to corneal perforation in the central China region. HSK and Mooren’s ulcers are common causes of repetitive corneal perforation. The complications associated with corneal perforation are common and often serious; therefore prevention and early treatment are very important in clinic.
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