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Shawn M. Iverson, Mitra Sehi, Ben Harvey, David S. Greenfield, Advanced Imaging for Glaucoma Study Group; Evaluation of Optic Disc Progression in Glaucoma using Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):214.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the rate of optic nerve head (ONH) progression measured using spectral domain optical coherence tomography (SDOCT) in glaucoma suspect and glaucomatous eyes with visual field progression.
Both eyes of glaucoma suspect and glaucoma patients in Advanced Imaging in Glaucoma Study with ≥30 months of follow-up underwent standard automated perimetry (SAP, 24-2 SITA Standard) and SDOCT (RTVue, Optovue Inc, Fremont, CA) measurements every 6 months. Inclusion criteria consisted of age between 40 and 85 years, refractive error spherical equivalent between -8.00D and +4.00D, best corrected visual acuity ≥20/40, reliable SAP (<33% fixation loss, false positive and false negative rates) and no prior intraocular surgery except for uncomplicated cataract extraction. SDOCT Images obtained during eye movement, or images that were unfocused, poorly centered or had a scan score index of ≥30 were excluded. Functional progression was defined as a significant (p<0.05) negative slope of visual field index (VFI) over time.
One hundred sixty eyes consisting of 96 glaucoma suspect and 64 glaucomatous eyes were enrolled (mean age 64±9.2, mean follow-up 37.7±5.1 months). 21 eyes had SAP progression. Rates of ONH loss were significantly faster in progressing compared with non-progressing eyes for cup area (p=0.03), ONH volume (p=0.02), rim volume (p=0.007), and horizontal (p=0.02), vertical (p=0.006) and overall C/D ratios (p=0.01).
Rate of ONH progression is faster in glaucoma suspect and glaucomatous eyes with SAP progression.
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