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Gabor Hollo, Farzaneh Naghizadeh, Anita Garas, Peter Vargha; Detection of Early Glaucomatous Progression with the RTVue Optical Coherence Tomograph and Scanning Laser Polarimetry. Invest. Ophthalmol. Vis. Sci. 2012;53(14):220.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the ability of RTVue-100 FD OCT to that of GDx-VCC and GDx-ECC to detect early glaucomatous progression.
1 eye of 110 patients (17 healthy, 20 OHT, 22 preperimetric and 51 perimetric glaucoma) were imaged prospectively in 6-month intervals for 1.5 to 3 years (median 2 years). VF Progression was determined by Hodapp's criteria modified for Octopus normal G2 test. Rate of progression (RoP)was expressed as relative (%) change/year.
Median MD RoP was 0.91, 0.11, -0.12 and -0.30 dB/year in the control, OHT, preperimetric and perimetric glaucoma group, respectively. The corresponding median RTVue-OCT avgRNFLT RoP values were -0.24, -0,50, -1.01 and -0.33 µm/year. 10 glaucoma eyes progressed by VF criteria with median MD RoP -0.516 dB/year (p=0.027 vs. controls) and median RoP for RTvue-OCT avgRNFLT -0.635 µm/year (p=0.098 vs. controls). Relative (%) variance of all RNFLT parameters was significantly (p<<0.001) smaller with RTVue-OCT than either GDx method. RNFLT progression did not differ significantly between the methods. No RNFLT and GCC parameter differed between the perimetric glaucoma and control groups but significantly (p<0.01) greater RoP was found for Rim Area, Inferior Rim Area, Rim Volume and Optic Nerve Head Volume in the perimetric glaucoma group (Table). Significantly higher RoP was seen for the functionally progressing eyes for RTVue-OCT Superior and Nasal Rim Area, and a tendency for greater RoP for Rim Area vs. the controls, but no difference was found for any RNFLT and GCC parameter (Table). The number of eyes with significant structural progression slopes was similar with all methods in all patient groups, with poor agreement with VF progression.
Long-term RNFLT measurements were less variable with the RTVue-OCT than either GDx method. For patient groups, early VF progression was associated with early structural progression, which was better detected with RTVue-OCT rim area and volume parameters than any RNFLT and GCC parameter. For individual eyes, early VF progression and statistically significant structural progression showed poor agreement, independently from the type of structural method and parameter used.
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