March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Long-term Glaucoma Progression Determined By HRT And HVFs
Author Affiliations & Notes
  • Eman Elhawy
    SUNY Downstate Medical Center, Brooklyn, New York
    SUNY Eye Institute, Brooklyn, New York
  • Martin Ma
    Mount Sinai school of Medicine, New York, New York
  • D. Chelsea Obourn
    SUNY Downstate Medical Center, Brooklyn, New York
    SUNY Eye Institute, Brooklyn, New York
  • Joshua Berkowitz
    Mount Sinai school of Medicine, New York, New York
  • Aaron Pickrell
    Mount Sinai school of Medicine, New York, New York
  • Donna J. Gagliuso
    Mount Sinai school of Medicine, New York, New York
  • Janet Serle
    Mount Sinai school of Medicine, New York, New York
  • John Danias
    SUNY Downstate Medical Center, Brooklyn, New York
    SUNY Eye Institute, Brooklyn, New York
  • Footnotes
    Commercial Relationships  Eman Elhawy, None; Martin Ma, None; D. Chelsea Obourn, None; Joshua Berkowitz, None; Aaron Pickrell, None; Donna J. Gagliuso, None; Janet Serle, None; John Danias, None
  • Footnotes
    Support  NEI RO1 EY15224, RPB, P30 EY01867
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 236. doi:
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    • Get Citation

      Eman Elhawy, Martin Ma, D. Chelsea Obourn, Joshua Berkowitz, Aaron Pickrell, Donna J. Gagliuso, Janet Serle, John Danias; Long-term Glaucoma Progression Determined By HRT And HVFs. Invest. Ophthalmol. Vis. Sci. 2012;53(14):236.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine whether HRT testing can identify the same eyes as progressing with those determined by visual field testing

Methods: : 252 patients with primary or secondary glaucoma or ocular hypertension, with at least 5 years of follow up and at least 6 reliable full threshold Humphrey visual fields (HVFs) and 6 HRT examinations were included. One eye was analyzed per patient in random. Glaucoma progression was determined separately for HVFs and HRTs by the presence of a statistically significant negative slope in mean deviation (MD), visual field index (VFI) or both and stereometric global HRT parameters respectively. The ability of HRT stereometric parameters to determine whether HVF change has occurred was calculated using ROC testing.

Results: : HVFs of 73 (29%), 84 (33%) and 61(24%) eyes showed progression as determined by MD, VFI or both respectively. HVF progression determined using MD was highly correlated with progression determined using the VFI (p<0.0007, logistic regression). HRTs of between 7(3%) and 48(19%) eyes showed progression as determined by global stereometric parameters. Certain similarly unrelated HRT stereometric parameters were also highly correlated (e.g. rim area and height variation contour - p<0.0002). The ability of the HRT stereometric parameters or combinations in determining whether HVF change has occurred was limited. Mean RNFL thickness performed best with only ~20% sensitivity at 90%sensitivity (p<0.05, z-test for AUC).

Conclusions: : HRT imaging detects progression in a different set of eyes from those detected by HVF testing

Keywords: visual fields • optic nerve • imaging/image analysis: clinical 
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