March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Baseline Retrobulbar Blood Flow is Predictive of Retinal Nerve Fiber Layer Thickness in Patients with Glaucoma
Author Affiliations & Notes
  • Ingrida Januleviciene
    Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Brent A. Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Melanie A. Pickett
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Erin Stewart
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Rita Ehrlich
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • John Abrams
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Miriam Zalish
    Ophthalmology, Kaplan Medical Center, Rehovot, Israel
  • Chi-Wah R. Yung
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Footnotes
    Commercial Relationships  Ingrida Januleviciene, None; Alon Harris, Pfizer (C); Brent A. Siesky, None; Melanie A. Pickett, None; Erin Stewart, None; Rita Ehrlich, None; John Abrams, None; Miriam Zalish, None; Chi-Wah R. Yung, None
  • Footnotes
    Support  Unrestricted grant from Research to Prevent Blindness and Pfizer Pharmaceuticals
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 242. doi:
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    • Get Citation

      Ingrida Januleviciene, Alon Harris, Brent A. Siesky, Melanie A. Pickett, Erin Stewart, Rita Ehrlich, John Abrams, Miriam Zalish, Chi-Wah R. Yung; Baseline Retrobulbar Blood Flow is Predictive of Retinal Nerve Fiber Layer Thickness in Patients with Glaucoma. Invest. Ophthalmol. Vis. Sci. 2012;53(14):242.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine if baseline retrobulbar blood flow as measured by color Doppler imaging (CDI) is predictive of retinal nerve fiber layer (RNFL) thickness in patients with open angle glaucoma (OAG).

Methods: : CDI and optical coherence tomography (OCT) parameters at baseline were analyzed as predictors of RNFL thickness after 2 years of follow up using Pearson correlation coefficients.

Results: : In 100 patients with OAG, baseline retrobulbar blood flow parameters were positively correlated with 2-year retinal nerve fiber layer (RNFL) thickness measurements. Ophthalmic artery (OA) end diastolic velocity (EDV) at baseline was positively correlated to 2-year inferior RNFL thickness (r=0.2, p=0.0432), temporal RNFL thickness (r=0.22, p=0.0252), and RNFL average thickness (r=0.25, p=0.0129) as measured by OCT. Central retinal artery (CRA) peak systolic velocity (PSV) at baseline was positively correlated with 2-year superior RNFL thickness (r=0.27, p=0.0062), nasal RNFL thickness (r=0.28, p=0.0045), and average RNFL thickness (r=0.27, p=0.0064). CRA EDV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.23, p=0.0193), nasal RNFL thickness (r=0.22, p=0.0295), and average RNFL thickness (r=0.24, p=0.014). Nasal posterior ciliary artery (NPCA) PSV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.32, p=0.0013), inferior RNFL thickness (r=0.24, p=0.0177), nasal RNFL thickness (r=0.23, p=0.0246), and RNFL average thickness (r=0.29, p=0.0037). NPCA EDV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.38, p=0.0001), inferior RNFL thickness (r=0.33, p=0.0009), nasal RNFL thickness (r=0.24, p=0.017), and RNFL average thickness (r=0.37, p=0.0001). Temporal posterior ciliary artery (TPCA) PSV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.28, p=0.0051). TPCA EDV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.3, p=0.0024) and RNFL average thickness (r=0.22, p=0.0313).

Conclusions: : In this cohort of patients with OAG, a positive correlation was found between baseline retrobulbar blood flow and RNFL thickness after 2 years. Baseline retrobulbar blood flow, as measured by CDI, may help predict 2-year RNFL measurements in patients with OAG.

Keywords: blood supply • neuroprotection • retina 
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