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Sung Soo Kim, Hyeong Eun Kim; Retinal Vascular Caliber Changes on OCT after Intravitreal Bevacizumab Injection in Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2012;53(14):345.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate retinal vascular caliber changes with Spectral Domain OCT after intravitreal Bevacizumab injection in diabetic macular edema patients
34 eyes of 29 diabetic macular edema patients who were injected Bevacizumab(1.25g/0.05ml) intravitreously were studied. 24 fellow eyes of 24 patients with Bevacizumab injection were also recruited as a control group. We measured retinal vascular caliber at 0.5~1 disc size apart from disc margin with Spectral Domain OCT at the baseline, 1 month and 3 months follow-up visits. Central macular thicknesses were also measured.
Over the 3 months of studies, there was a significant reduction of arteriolar caliber at 3 months compared to baseline (p=0.024), There were significant reduction of venular caliber at 1 month(p=0.001) and 3 months(p=0.000) compared to baseline. Venymliular caliber reduction at 3 months follow-up was significantly correlated with central macular thickness(R=0.487, p=0.003).
Retinal venular caliber reduction was significant at 1 and 3 months follow-up and arteriolar caliber reduction was significant at 3 months follow-up compared to baseline. After 3 months of treatment, venular caliber reduction was correlated with reduction of central macular thickness.
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