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Su-Na Lee, Jay Chhablani, Haiyan Wang, Giulio Barteselli, Sharif El Emam, Igor Kozak, Lingyun Cheng, William R. Freeman; Fluorescein Angiography And SD-OCT Analysis Of Lasered Microaneurysms In Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2012;53(14):408.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the changes of microaneurysms (MAs) and to evaluate the closure rate of MAs on fluorescein angiography (FA) and spectral domain optical coherence tomogram (SD-OCT) after navigated focal laser photocoagulation in eyes with diabetic macular edema (DME).
We investigated 16 eyes of 12 patients treated with navigated retinal laser photocoagulator Navilas® (OD-OS, Teltow, Germany) for DME . The eyes that underwent simultaneous FA and SD-OCT (Spectralis, Heidelberg Engineering, Vista, CA) at baseline and after photocoagulation, were included. Ninety-seven raster scans per eye were used to detect the change of MAs at the same location after photocoagulation. Baseline FA leakage score (0=no leakage, 1=mild leakage, 2=severe leakage), SD-OCT characteristics (MA size, location, retinal thickness) and closure rate of MAs after photocoagulation were analyzed by two masked observers.
Seventy nine MAs were analyzed and mean follow up period after photocoagulation was 8.65 month. At baseline, mean FA leakage score was 1.38 ± 0.56 and average MA size was 92.83 ± 31.37 μm. Most of MAs (68.35%) were located at the inner nuclear and inner plexiform layers. After photocoagulation, mean retinal thickness decreased by 74.79 ± 119.78 μm (p<0.0001), and the percentage of closed MAs was 82.28 % on SD-OCT and 77.22 % on FA. The closure rate of MAs by OCT was negatively associated with the size of MAs (p=0.001).
The changes of MAs after navigated focal laser photocoagulation could be studied on simultaneous FA and SD-OCT. Percentage of closed MAs was 82.28 % and 77.22 % on SD-OCT and FA, respectively. The closure rate of MAs was negatively associated with the size of MAs in eyes with DME.
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