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Xavier RICAUD, Ghislaine RABUT, Christophe Baudouin, Alexandre Denoyer; Corneal Aberrations And The Quality Of Vision In Dry Eye Disease. Invest. Ophthalmol. Vis. Sci. 2012;53(14):567.
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To investigate the relationships between dynamic optical quality of the eye and patient-reported vision-related quality of life in dry eye disease.
Forty patients diagnosed for low- to moderate-severity dry eye underwent clinical examination (tear film break-up time [TBUT], Schirmer's test, corneal and conjunctival stainings, and blepharitis scoring)and corneal/ocular higher-order aberration (HOA) recording (1 measurement/s during 10 s after blinking) using KR-1 aberrometer (Topcon, Clichy, France). Vision-related quality of life was assessed using the Ocular Surface Disease Index (OSDI) questionnaire. Multivariate analysis combined with stepwise regression procedure was performed to determine correlations between the data.
Significant progression of corneal HOAs was found (repeated-measure one-way ANOVA, P<0.01 from 4 s to 10 s after blinking)together with degradation in Point Spread Function and three-dimensional Modulation Transfer Function, mainly due to an increase with time in 3rd-order aberrations. The progression index for HOAs was correlated with clinical objective findings of TBUT and ocular surface damage (P<0.01 for each) as well as with subjective OSDI score (P<0.05).
Targeted analysis of the time-course of HOAs and related optical properties of the eye could become an objective and reliable tool to evaluate and follow the disease severity in dry eye.
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