March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Corneal Aberrations And The Quality Of Vision In Dry Eye Disease
Author Affiliations & Notes
  • Xavier RICAUD
    Quinze-Vingts National Ophthalmology Hospital, Paris, France
  • Ghislaine RABUT
    Quinze-Vingts National Ophthalmology Hospital, Paris, France
  • Christophe Baudouin
    Quinze-Vingts National Ophthalmology Hospital, Paris, France
    Institut de la Vision/INSERM/UPMC Univ Paris 06/CNRS, Paris, France
  • Alexandre Denoyer
    Quinze-Vingts National Ophthalmology Hospital, Paris, France
    Institut de la Vision/INSERM/UPMC Univ Paris 06/CNRS, Paris, France
  • Footnotes
    Commercial Relationships  Xavier Ricaud, None; Ghislaine Rabut, None; Christophe Baudouin, None; Alexandre Denoyer, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 567. doi:
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      Xavier RICAUD, Ghislaine RABUT, Christophe Baudouin, Alexandre Denoyer; Corneal Aberrations And The Quality Of Vision In Dry Eye Disease. Invest. Ophthalmol. Vis. Sci. 2012;53(14):567.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the relationships between dynamic optical quality of the eye and patient-reported vision-related quality of life in dry eye disease.

Methods: : Forty patients diagnosed for low- to moderate-severity dry eye underwent clinical examination (tear film break-up time [TBUT], Schirmer's test, corneal and conjunctival stainings, and blepharitis scoring)and corneal/ocular higher-order aberration (HOA) recording (1 measurement/s during 10 s after blinking) using KR-1 aberrometer (Topcon, Clichy, France). Vision-related quality of life was assessed using the Ocular Surface Disease Index (OSDI) questionnaire. Multivariate analysis combined with stepwise regression procedure was performed to determine correlations between the data.

Results: : Significant progression of corneal HOAs was found (repeated-measure one-way ANOVA, P<0.01 from 4 s to 10 s after blinking)together with degradation in Point Spread Function and three-dimensional Modulation Transfer Function, mainly due to an increase with time in 3rd-order aberrations. The progression index for HOAs was correlated with clinical objective findings of TBUT and ocular surface damage (P<0.01 for each) as well as with subjective OSDI score (P<0.05).

Conclusions: : Targeted analysis of the time-course of HOAs and related optical properties of the eye could become an objective and reliable tool to evaluate and follow the disease severity in dry eye.

Keywords: cornea: tears/tear film/dry eye • aberrations • quality of life 
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