March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
The Effectiveness Of Long Term Treatments For Meibomian Gland Dysfunction: A Retrospective Study
Author Affiliations & Notes
  • David E. Wang
    Robert Cizik Eye Clinic, Houston, Texas
  • John Awad
    Robert Cizik Eye Clinic, Houston, Texas
  • Blake Harp
    University of Texas Health Science Center, Houston, Texas
  • Alice Chuang
    University of Texas Health Science Center, Houston, Texas
  • Richard W. Yee
    Robert Cizik Eye Clinic, Houston, Texas
  • Footnotes
    Commercial Relationships  David E. Wang, None; John Awad, None; Blake Harp, None; Alice Chuang, None; Richard W. Yee, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 608. doi:
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      David E. Wang, John Awad, Blake Harp, Alice Chuang, Richard W. Yee; The Effectiveness Of Long Term Treatments For Meibomian Gland Dysfunction: A Retrospective Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):608.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Current treatments of MGD are aimed at unplugging the meibomian glands, altering meibum, and controlling inflammation on a short-term interval, typically days to weeks. Unfortunately, there has not been a comprehensive study evaluating the effectiveness of current collective treatments of MGD over longer intervals i.e. months to years. This study aims at taking the first step towards a longer-term comprehensive assessment of our current treatment approach of MGD.

Methods: : A total of 82 patients were given a treatment regimen for both signs and symptoms of MGD. Efficacy of the treatments was assessed by basal tear test and ratings of 0-4 (0 = none, 4=severe) for anterior blepharitis, lid margin vascularity, MG obstruction and meibum turbidity for OS and OD. Baseline data were compared with follow-up data at 0-3 months, 3-6 months, 6-12 months and 1 year + using a paired t-test.

Results: : Statistically significant improvements were noted for anterior blepharitis and MG obstruction at all time points. Anterior blepharitis scores improved by 0.79 and 0.78 points in the 0-3 month group and 1.00 and 0.92 in the 3-6 month follow-up group OD and OS respectively. MG obstruction improved 0.68 in the lower left lid in the 0-3 month group at 1.43 and 1.86 points in the 1 year + follow-up group OD and OS respectively. In all cases there was no data indicating that the patients were getting worse on chronic treatment regimens.

Conclusions: : This study shows that our current treatment approach of MGD do in fact have a positive impact on patients’ signs and symptoms.

Keywords: cornea: tears/tear film/dry eye • clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology • cornea: clinical science 
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