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Mona K. Garvin, Michael D. Abràmoff, Kyungmoo Lee, Meindert Niemeijer, Milan Sonka, Young H. Kwon; A Structure-Structure-Based Correlation Map Using SD-OCT Resembles Nerve Fiber Bundle Patterns in Glaucoma Subjects. Invest. Ophthalmol. Vis. Sci. 2012;53(14):667.
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To correlate the thicknesses of focal regions of the macular ganglion cell layer with those of the peripapillary nerve fiber layer using spectral-domain optical coherence tomography (SD-OCT) in two groups of subjects: those with glaucoma and those with glaucoma suspicion.
Macula and optic-nerve-head SD-OCT volumes were obtained in 30 eyes of 30 subjects with open-angle glaucoma and in 27 eyes of 27 subjects with glaucoma suspicion. Using a custom automated computer algorithm, the thickness of 66 macular ganglion cell layer regions and the thickness of 12 peripapillary nerve fiber layer regions were measured from registered SD-OCT volumes. The mean thickness of each ganglion-cell-layer region was correlated to the mean thickness of each peripapillary-nerve-fiber-layer region across subjects in the two groups. Within each group, each ganglion-cell-layer region was labeled with the peripapillary-nerve-fiber-layer region with the highest correlation using a color-coded map.
The resulting color-coded map from the glaucoma group closely resembled the nerve-fiber-bundle pattern of retinal ganglion cells, but less of a resemblance was observed in the glaucoma-suspicion group (see Figure). The r2 value across all local macular-peripapillary correlations was significantly larger in the glaucoma group (0.56 ± 0.13 versus 0.37 ± 0.11; p < 0.001).
A 2-D spatial nerve-fiber-bundle (NFB) map of the retina can be developed using structure-structure relationships from SD-OCT, with such a map more closely resembling expected nerve fiber bundles when constructed from subjects with definite glaucoma. The focal nature of the NFB damage in the analyzed glaucoma subjects was likely a critical factor in obtaining such a resemblance.
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