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Sonya B. Shah, Alberto G. Garcia, Jonathan S. Myers, Laurie Cox, L. J. Katz; Color Reflectivity Discretization Analysis (CORDA) Of OCT Images In The Detection Of Glaucomatous Retinal Nerve Fiber Layer (RNFL) Damage. Invest. Ophthalmol. Vis. Sci. 2012;53(14):670.
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© ARVO (1962-2015); The Authors (2016-present)
To compare a new method to analyze the different anatomic components of internal RNFL structure and to evaluate its ability to discriminate healthy eyes and eyes with glaucomatous visual field defects.
24 eyes of 12 patients with mild to advanced glaucomatous visual field loss and 24 eyes of 12 healthy subjects were included in this study. Visual field testing, OCT imaging and CORDA for OCT images were completed for each participant. CORDA is a method developed to evaluate the various components of the RNFL from OCT images. The software performs an image analysis to quantify the amount of four predefined data points with different reflectivity levels. The CORDA HR2 (a high reflectivity parameter) represents the proportional axonal population of the RNFL. Areas under the receiver operating characteristic (ROC) curve were obtained for these parameters.
Significant differences were found between healthy and glaucomatous eyes for all CORDA parameters except for HR1. The best correlation between RNFL thickness and CORDA parameters was for HR2 at Superior and Inferior sectors (r=0.6). The AROC value for the HR2 parameter was 0.94.
CORDA parameters correlate well with RNFL thickness and show high area under ROC values. These results suggest significant potential for CORDA parameters to discriminate between normal and glaucomatous eyes.
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