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Marlene Francoz, Jean-Remi Fenolland, Jean-Marie Giraud, Hussam El Chehab, Damien Sendon, Fouad El Asri, Mamour Dieng, Charlotte Denier, Franck May, Jean-Paul Renard; Reproducibility of Macular Ganglion Cell-Inner Plexiform Layer thickness measurement with SD-Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):689.
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To use spectral-domain optical coherence tomography (SD-OCT) to measure macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness with automated detection and evaluate the intra and inter-observer reproducibility in normal, hypertensive and glaucomatous eyes.
A total of 87 eyes were enrolled in 3 goups : (1) normal subjects (n=28); (2) ocular hypertensive subjects (n=31); (3) open angle glaucoma patients (n=28). All patients underwent a complete examination including biomicroscopy, 24-2 automated perimetry, biometry and pachymetry. Each eye underwent macular scanning using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) 3 times by each of 2 investigators. Macular GCIPL thickness was measured using the ganglion cell analysis (GCA) algorithm to provides parameters as average, minimum and 6 sectoral thicknesses. The reproducibility was assessed by the coefficient of variation (CV) and the intraclass correlation coefficient (ICC).
The mean GCIPL thickness was 81.2 ± 7.4 μm, 76.6 ± 7.3 μm and 63.3 ± 8.7 μm in group 1, 2 and 3 respectively. The mean GCIPL was not significantly different between normal and ocular hypertensive subjects (p=0.3) but significantly lower in glaucomatous eyes (p<0.0001 vs. group 1 and group 2). For the mean GCIPL, CV ranges of intra- and interobserver evaluation were 0.7-0.8% and 1.1-2.2 % respectively. The ICC ranges of intra- and interobserver evaluation were 99.5-99.9 % and 99.1-99.7 % respectively.
To our knowledge this is the first study of GCA algorithm reproducibility on normal and glaucomatous eyes. Reproducibilty of GCIPL thickness measure using Cirrus HD-OCT GCA algorithm is highly satisfactory in normal, ocular hypertensive and glaucoma subjects. GCIPL parameters might be promising new OCT parameters for glaucoma diagnosis and follow-up.
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