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Farzaneh Naghizadeh, Anita Garas, Péter Vargha, Gabor Hollo; Structure-function Relationship Between Octopus Perimeter Cluster Mean Sensitivity and Sector Retinal Nerve Fiber Layer Thickness Measured with the RTVue OCT, GDx-VCC and GDx-ECC. Invest. Ophthalmol. Vis. Sci. 2012;53(14):706.
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© ARVO (1962-2015); The Authors (2016-present)
To determine structure-function relationship between each of 16 Octopus perimeter G2 program clusters and the corresponding 16 peripapillary sector retinal nerve fiber layer thickness (RNFLT) values measured with the RTVue-100 FD OCT and GDx-VCC/ECC.
1 eye of 110 Caucasian patients (15 healthy, 20 OHT, 75 glaucoma) was investigated prospectively for 1.5 to 3 years with 6-month intervals (568 visits). Octopus perimetry (normal G2 program), RTvue-OCT, GDx-VCC/ECC examinations were made in all visits. Robust regression analysis was used to evaluate structure-function relationship.
For all participants, parabolic (y=a+bx+cx2) structure-function relationship was found for the cluster mean sensitivity (MS) and mean defect (MD) values. For RTVue-OCT significant (p<0.0001) coefficients of determination (R2) were found for all 16 RNFLT sectors (Table). The R2 values were highest for the 2 superotemporal (0.4483 and 0.4099) and 2 inferotemporal sectors (0.4975 and 0.4466) respectively. For GDx-VCC significant (p<0.01) R2 values were seen for all but 1 temporal, for GDx-ECC for all but 2 temporal and 1 nasal sectors. Significantly higher R2 values were seen for RTVue-OCT than any GDx method for inferotemporal sectors. For superotemporal and inferotemporal sectors R2 values with GDx-ECC were consistently higher than with GDx-VCC.
MS and MD values of the Octopus visual field clusters showed significant parabolic relationship with the corresponding peripapillary RNFLT sectors. The relationship was more general with the RTVue-OCT than GDx-VCC or GDx-ECC. The results show that visual field clusters of the Octopus G program can be applied for detailed structure-function research.
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