Purpose:
To determine structure-function relationship between each of 16 Octopus perimeter G2 program clusters and the corresponding 16 peripapillary sector retinal nerve fiber layer thickness (RNFLT) values measured with the RTVue-100 FD OCT and GDx-VCC/ECC.
Methods:
1 eye of 110 Caucasian patients (15 healthy, 20 OHT, 75 glaucoma) was investigated prospectively for 1.5 to 3 years with 6-month intervals (568 visits). Octopus perimetry (normal G2 program), RTvue-OCT, GDx-VCC/ECC examinations were made in all visits. Robust regression analysis was used to evaluate structure-function relationship.
Results:
For all participants, parabolic (y=a+bx+cx2) structure-function relationship was found for the cluster mean sensitivity (MS) and mean defect (MD) values. For RTVue-OCT significant (p<0.0001) coefficients of determination (R2) were found for all 16 RNFLT sectors (Table). The R2 values were highest for the 2 superotemporal (0.4483 and 0.4099) and 2 inferotemporal sectors (0.4975 and 0.4466) respectively. For GDx-VCC significant (p<0.01) R2 values were seen for all but 1 temporal, for GDx-ECC for all but 2 temporal and 1 nasal sectors. Significantly higher R2 values were seen for RTVue-OCT than any GDx method for inferotemporal sectors. For superotemporal and inferotemporal sectors R2 values with GDx-ECC were consistently higher than with GDx-VCC.
Conclusions:
MS and MD values of the Octopus visual field clusters showed significant parabolic relationship with the corresponding peripapillary RNFLT sectors. The relationship was more general with the RTVue-OCT than GDx-VCC or GDx-ECC. The results show that visual field clusters of the Octopus G program can be applied for detailed structure-function research.
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical • visual fields