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Lauren E. Doss, Linden R. Doss, Travis C. Porco, Shan C. Lin; The Relationship of Central Corneal Thickness to Both Retinal Nerve Fiber Layer Thickness and Cup-to-Disk Ratio in Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2012;53(14):729.
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Central corneal thickness (CCT) is a powerful predictor of glaucomatous development. We attempt to determine the relationship between CCT and retinal nerve fiber layer (RNFL) thickness and cup-to-disc (C/D) ratio obtained by confocal scanning laser ophthalmoscopy (HRT II; Heidelberg Engineering, Heidelberg, Germany) and Fourier-domain optical coherence tomography (FD-OCT, RTVue, Optovue; Fremont, CA) .
One hundred and twenty healthy subjects (mean age 24.8±3.0) were enrolled in this single-center, prospective cross-sectional study. All subjects had a standard clinical examination by a single experienced examiner, as well as visual field (VF) and good-quality scans from both imaging devices. CCT was measured using an anterior chamber OCT (Visante AS-OCT; Carl Zeiss Meditec, Dublin, CA). A linear mixed-effects model was used to assess the relationship between RNFL thickness and C/D to CCT, accounting for clustering of eyes within subjects, refraction, ethnicity, family history of glaucoma, axial length, intraocular pressure, and VF global indices.
For FD-OCT (p=0.018) and HRT (p=2.03e-6), there was a statistically significant positive relationship between CCT and RNFL thickness (R=0.09 and 0.25, respectively). However, there was no relationship to C/D with either modality (p>0.05).
CCT was significantly related to RNFL thickness and not related to C/D ratio in healthy eyes, as measured by HRT II and FD-OCT.
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