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Carmela Carnevale, Serena Salvatore, Yu-hui Huang, Pasquale Plateroti, Serena Fragiotta, Roberto Grenga; Fixation Behavior Characteristics In Different Retinal Diseases. Invest. Ophthalmol. Vis. Sci. 2012;53(14):809.
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To evaluate fixation behavior in patients with retinitis pigmentosa (RP) and diabetic retinopathy (DR) using the MP-1 microperimeter (Nidek Technologies,Italy).
Thirty healthy people (group A), 26 people with RP (group B), and 28 people with DR (group C) were assessed. Groups were paired by age and gender. BCVA, retinal sensitivity within central 2 and 4 degrees were evaluated. Fixation score, central 2 and 4 degrees values and bivariate contour ellipse area (BCEA) were obtained from the MP-1. Statistical analysis was performed with Student’s t-test. Values < 0.05 were considered significant. Pearson’s correlation coefficient was calculated for comparisons.
Fixation within the 2° diameter circle was 93.53±5.97% for group A, 82.00±23.31 for group B (p<0.05), and 78.13±21.61 for group C (p<0.05). Fixation within the 4° diameter circle was 97.93±2.99% for group A, 93.00±14.42 for group B (0.11) and 95.13±4.91 for groups C (0.6). Retinal sensitivity within the 2°was 17.66±2.37dB for group A, 14.47±5.06 dB for group B (0.13), and 14.54±6.06 for group C (0.2). Retinal sensitivity within the 4° was 18.05±1.41dB for group A, 14.55±4.95 for group B (0.7), and 15.69±4.23 for group C (0.4). BCEA which contained 99% fixation points was 11.11±10.55 degree sq. for group A, 20.91±33.28for group B (0.002), and 16.25±14.37for group C (0.001). BCVA was 0 ±0.96,0 ±1.14, and 0±0.94 logMAR respectively. A significant correlation was found between BCVA and BCEA (r= 0.99) for all groups.
Although a significant difference was found between fixation behavior within the 2° diameter circles in all groups, the only fixation parameter that correlated with BCVA was BCEA, which could differentiate subtle changes in macular function. Thus, we recommend BCEA to be used to quantify fixation stability when using MP-1.
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