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Nazli Demirkaya, Hille W. van Dijk, Reinier O. Schlingemann, Michael D. Abramoff, Mona K. Garvin, Milan Sonka, Frank D. Verbraak; Pericentral Ganglion Cell Layer Thickness Decreases with Age in Normal Eyes as Measured by Spectral-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):823.
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To determine the effect of age on individual retinal layer thicknesses in healthy subjects measured by Spectral-Domain Optical Coherence Tomography.
Eighty-four healthy subjects with an age ranging between 18 and 70 years were examined with Spectral-Domain Optical Coherence Tomography (SD-OCT, Topcon, Marck II). Mean layer thickness was calculated for 7 retinal layers, in the central area (region 1 of the 9 ETDRS regions), in the pericentral area (ETDRS regions 2 to 5), and the peripheral area (ETDRS region 6 to 9) following automated segmentation using a custom made algorithm, which uses a fully three-dimensional graph search approach. To avoid the influence of confounders like gender and axial length we calculated for each layer in each area the ratio Mean Layer Thickness/ Total Retinal Thickness (Mean LT/Mean Total RT). The Pearson correlation test was performed for each retinal layer to determine the relationship between age and the ratio Mean LT/Mean Total RT.
There was a significant negative correlation between the Mean LT/Mean Total RT ratio of the pericentral ganglion cell layer and age (R=-0,300, P=0,006). All other pericentral layer ratios and all layer ratios in the central and peripheral areas did not show significant change in thickness with age.
This study demonstrates in healthy individuals a thinning of the ganglion cell layer in the pericentral area with increasing age.
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