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Pamela A. Weber, Tugce Karalar, James Soque; Changes in Retinal Nerve Fiber Layer in Eyes Treated with AntiVEGF Intraocular Injections for Neovascular AMD. Invest. Ophthalmol. Vis. Sci. 2012;53(14):877.
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to evaluate loss of the RNFL in eyes receiving multiple intraocular injections of anti-VEGF medications for the treatment of neovascular age-related macular degeneration (NVAMD).
eyes with NVAMD that had a Stratus RNFL analysis followed by a 2nd study at least 48 months later were included.The eye had to have a signal stregth of 4 or better on OCT, a minimum of 5 injections of an antiVEGF drug, and no history of glaucoma. Untreated fellow eyes were used as controls.
We identified 29 eyes of 22 patients. There were 12 untreated fellow eyes that were analyzed as controls.Eyes received from 5-40 injections:mean and median 19 and 18. There was no change in the RNFL when comparing the treated to the controls (p=0.663). More intense treatment was not associated with decreases in RNFL.The baseline and follow-up average RNFL for treated eyes were 88.24(+11.1) and 83.66(+9.52)(p=0.101). and for controls were 88.92(+12.87) and 85.00(+10.05)(p=0.11).
there was no statistically significant change in the RNFL assocated with intraocular antiVEGF drugs for the treatment of NVAMD in eyes followed for at least 4 years.
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