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Syed A. Ali, Rajeev K. Seth; Response of Foveal Cysts to Carbonic Anhydrase Inhibitors in X-Linked Retinoschisis. Invest. Ophthalmol. Vis. Sci. 2012;53(14):959.
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To describe the response of foveal cysts to carbonic anhydrase inhibitors in X-Linked Retinoschisis.
A 54 year old monocular female with a family history of consanguinity and X-linked retinoschisis in her son and several other relatives was referred to the retina clinic after her vision failed toimprove in her left eye after cataract surgery. Her visual acuity was 20/70 on presentation. X-linked retinoschisis was diagnosed after exam revealed stellate maculopathy with foveal cysts confirmed by OCT (Image 1), peripheral retinoschisis, FA revealing no late leakage, and ERG showing loss of B wave amplitude.
One month after a trial of oral acetazolamide 500mg BID, she noted subjective visual improvement with acuity of 20/70 ,and the OCT showed significant improvement in her foveal cyst (Image 2). She was then switched to topical dorzolamide, and nine months after initiation, her vision remained stable with no recurrence of the foveal cyst.
Carbonic anhydrase inhibitors can be efficacious in treating the cysts associated with X-Linked Retinoschisis. Further trials are warranted to ascertain the efficacy of carbonic anhydrase inhibitors in XLRS.
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