March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Prevalence and Associations of Myelinated Retinal Nerve Fibers: The Gutenberg Health Study (GHS)
Author Affiliations & Notes
  • Norbert Pfeiffer
    Ophthalmology,
    University Medical Center Mainz, Mainz, Germany
  • Christina Butsch
    Ophthalmology,
    University Medical Center Mainz, Mainz, Germany
  • Isabella Zwiener
    Institute of Medical Biostatistics, Epidemiology and Informatics,
    University Medical Center Mainz, Mainz, Germany
  • Philipp S. Wild
    Medicine II - Cardiology,
    University Medical Center Mainz, Mainz, Germany
  • Alireza Mirshahi
    Ophthalmology,
    University Medical Center Mainz, Mainz, Germany
  • Footnotes
    Commercial Relationships  Norbert Pfeiffer, None; Christina Butsch, None; Isabella Zwiener, None; Philipp S. Wild, None; Alireza Mirshahi, None
  • Footnotes
    Support  Government of Rheinland-Pfalz (contract number AZ 961-386261/733), University Medical Center Mainz, Boehringer Ingelheim, Germany, PHILIPS Medical Systems
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 999. doi:
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      Norbert Pfeiffer, Christina Butsch, Isabella Zwiener, Philipp S. Wild, Alireza Mirshahi; Prevalence and Associations of Myelinated Retinal Nerve Fibers: The Gutenberg Health Study (GHS). Invest. Ophthalmol. Vis. Sci. 2012;53(14):999.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the prevalence and ocular and systemic associations of myelinated retinal nerve fibers (MRNF) in a large adult Caucasian cohort.

Methods: : GHS is a population-based, prospective, observational cohort study in the Rhine-Main Region in midwestern Germany with a total of about 15000 participants aged between 35 and 74 years at the time of the exam. A follow-up is scheduled in five years. Participants undergo a standardized protocol with a comprehensive questionnaire, an ophthalmic examination including slitlamp biomicroscopy, non-contact tonometry, fundus photography, central corneal thickness measurement and visual field testing. Furthermore, a complete general examination focused on cardiovascular parameters, psychosomatic evaluations and laboratory tests including genetic analysis are performed. The first 5000 participants, who are stratified by gender, residence (urban and rural) and decade of age, were included into this analysis. Optic disc photographs (30° and 45°) and macular photographs (30°) were reviewed to assess prevalence of MRNF. Association analyses with ocular and cardiovascular parameters were performed.

Results: : Fundus photographs of 9092 eyes (4542 right and 4550 left) were eligible for evaluation. 10 eyes of 10 subjects (0.11%) showed lesions of MRNF (3 right and 7 left eyes). No association was found for cardiovascular risk factors, such as blood pressure, diabetes, smoking or body mass index. Similarly, no statistically significant association was found for ocular parameters including central corneal thickness, refraction, intraocular pressure and visual field defects.

Conclusions: : To our knowledge this is the first population-based study providing data on the prevalence of myelinated retinal nerve fibers in Caucasians. Prevalence of MRNF in this European cohort is lower than in previous population-based studies in Asians and autopsy-based data in North-Americans.

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • optic nerve • retinal glia 
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