Purchase this article with an account.
Norbert Pfeiffer, Christina Butsch, Isabella Zwiener, Philipp S. Wild, Alireza Mirshahi; Prevalence and Associations of Myelinated Retinal Nerve Fibers: The Gutenberg Health Study (GHS). Invest. Ophthalmol. Vis. Sci. 2012;53(14):999.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To determine the prevalence and ocular and systemic associations of myelinated retinal nerve fibers (MRNF) in a large adult Caucasian cohort.
GHS is a population-based, prospective, observational cohort study in the Rhine-Main Region in midwestern Germany with a total of about 15000 participants aged between 35 and 74 years at the time of the exam. A follow-up is scheduled in five years. Participants undergo a standardized protocol with a comprehensive questionnaire, an ophthalmic examination including slitlamp biomicroscopy, non-contact tonometry, fundus photography, central corneal thickness measurement and visual field testing. Furthermore, a complete general examination focused on cardiovascular parameters, psychosomatic evaluations and laboratory tests including genetic analysis are performed. The first 5000 participants, who are stratified by gender, residence (urban and rural) and decade of age, were included into this analysis. Optic disc photographs (30° and 45°) and macular photographs (30°) were reviewed to assess prevalence of MRNF. Association analyses with ocular and cardiovascular parameters were performed.
Fundus photographs of 9092 eyes (4542 right and 4550 left) were eligible for evaluation. 10 eyes of 10 subjects (0.11%) showed lesions of MRNF (3 right and 7 left eyes). No association was found for cardiovascular risk factors, such as blood pressure, diabetes, smoking or body mass index. Similarly, no statistically significant association was found for ocular parameters including central corneal thickness, refraction, intraocular pressure and visual field defects.
To our knowledge this is the first population-based study providing data on the prevalence of myelinated retinal nerve fibers in Caucasians. Prevalence of MRNF in this European cohort is lower than in previous population-based studies in Asians and autopsy-based data in North-Americans.
This PDF is available to Subscribers Only