March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Corneal Involvement In Primary Biliary Cirrhosis: An In Vivo Confocal Microscopy Study
Author Affiliations & Notes
  • Angelica Dipinto
    Eye Clinic,
    San Paolo Hospital, Milan, Italy
  • Paolo Fogagnolo
    Fondazione GB Bietti-IRCCS, Rome, Italy
  • Massimo Zuin
    Internal Medicine,
    San Paolo Hospital, Milan, Italy
  • Mariangela Delliponti
    Internal Medicine,
    San Paolo Hospital, Milan, Italy
  • Maurizio Digiuni
    Eye Clinic,
    San Paolo Hospital, Milan, Italy
  • Laura Ottobelli
    Eye Clinic,
    San Paolo Hospital, Milan, Italy
  • Luca Rossetti
    Eye Clinic,
    San Paolo Hospital, Milan, Italy
  • Footnotes
    Commercial Relationships  Angelica Dipinto, None; Paolo Fogagnolo, None; Massimo Zuin, None; Mariangela Delliponti, None; Maurizio Digiuni, None; Laura Ottobelli, None; Luca Rossetti, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1079. doi:
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    • Get Citation

      Angelica Dipinto, Paolo Fogagnolo, Massimo Zuin, Mariangela Delliponti, Maurizio Digiuni, Laura Ottobelli, Luca Rossetti; Corneal Involvement In Primary Biliary Cirrhosis: An In Vivo Confocal Microscopy Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1079.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To investigate the corneal involvement in Primary Biliary Cirrhosis (PBC), a slowly progressive cholestatic liver disease of autoimmune etiology.

 
Methods:
 

Seven female patients affected by PBC underwent a slit-lamp biomicroscopy of the anterior segment with and without Goldmann's three-mirror contact lens, and laser scanning confocal microscopy (LSCM, Heidelberg Engineering Germany). LSCM images were acquired and analyzed for all layers of central and peripheral cornea (four quadrants).

 
Results:
 

All patients had normal findings both at slit-lamp biomicroscopy and at gonioscopy. Peculiar findings were shown at LSCM: all patients showed keratocytes activation (Figure 1); sub-basal nerve fibers with beadlike structure (Figure 2) were found in six patients (86%); four subjects (57%) had hyper-reflective stromal macro-deposits (Figure 2). No deposits suggestive for copper deposition were detected at the level of Descemet’s membrane.

 
Conclusions:
 

To the best of our knowledge this is the first confocal microscopy study on PBC patients. LSCM could show that subclinical corneal inflammation is a very common finding also in ophthalmoscopically normal patients affected by this autoimmune disease.  

 

 
Keywords: cornea: stroma and keratocytes • autoimmune disease 
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