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Pietro Biondi, Michele Reibaldi, Teresio Avitabile, Maurizio G. Uva, Cristina Cassar Scalia, Mario D. Toro, Silvio Zagari, Marco Zagari, Martina Battaglia, Livio M. Franco; IOP, CCT, corneal thinnest point and RNFL Thickness In Eyes With Keratoconus before and after corneal transepithelial cross-linking. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1102.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the intraocular pressure (IOP), the central corneal thickness (CCT), the corneal thinnest point and the thickness of peripapillary retinal nerve fiber layer (RNFL) obtained by Spectralis domain optical coherence tomography (OCT) in eyes with keratoconus, before and after transepithelial cross-linking.
In twenty-nine eyes of 29 patients (18 male, 11 female, mean age 30 ± 6,5) affected with stage I-III keratoconus (9 eyes stage I, 15 eyes stage II, 5 eyes stage III) that underwent transepithelial corneal cross-linking, IOP was measured by Goldmann applanation tonometer, CCT and corneal thinnest point were measured by Orbscan II (Bausch & Lomb, Salt Lake City, UT, USA) and peripapillary RNFL thickness was evaluated with Spectralis spectral domain OCT (Heidelberg Engineering, Heidelberg, Germany). Measurements were repeated before the treatment and after the treatment at the 1, 3, 6 months; for OCT measurements the follow-up function was used.
Intraocular pressure increased at 6 months; value was at baseline at 11.9±2 mmHg, and at 6 months 13.1±1.7 mmHg (ANOVA p=0.004, Tukey-Kramer p<0.01 vs baseline).No significant change were found in Central Corneal Thickness (baseline 459±48 microns), in corneal thinnest point (baseline: 431±50 microns), and in all sectors of RNFL thickness (average value: 95±8 microns).
Transepithelial corneal cross-linking does not affect values of CCT, corneal thinnest point and RNFL thickness; increased IOP values were found after six months by Goldmann applanation tonometry.
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