March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Anterior Corneal Surface Descriptors, Posterior Elevation and Pachymetric Progression in Normal and Subclinical Keratoconus as Assessed by Pentacam
Author Affiliations & Notes
  • Jonatan D. Galletti
    Ophthalmology, Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina
  • Marianella Delrivo
    ECOS (Clinical Ocular Studies) Laboratory, Buenos Aires, Argentina
  • Fernando Fuentes Bonthoux
    Ophthalmology, Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina
    ECOS (Clinical Ocular Studies) Laboratory, Buenos Aires, Argentina
  • Tomás Pförtner
    ECOS (Clinical Ocular Studies) Laboratory, Buenos Aires, Argentina
  • Jeremías G. Galletti
    Ophthalmology, Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina
    ECOS (Clinical Ocular Studies) Laboratory, Buenos Aires, Argentina
  • Footnotes
    Commercial Relationships  Jonatan D. Galletti, None; Marianella Delrivo, None; Fernando Fuentes Bonthoux, None; Tomás Pförtner, None; Jeremías G. Galletti, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1104. doi:
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      Jonatan D. Galletti, Marianella Delrivo, Fernando Fuentes Bonthoux, Tomás Pförtner, Jeremías G. Galletti; Anterior Corneal Surface Descriptors, Posterior Elevation and Pachymetric Progression in Normal and Subclinical Keratoconus as Assessed by Pentacam. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1104.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare corneal shape descriptors of the Pentacam Scheimpflug tomograph in healthy and subclinical keratoconus eyes to assess their diagnostic capacity.

Methods: : 22 eyes from 22 healthy subjects in group 1 and 26 eyes from 26 unilateral manifest keratoconus patients in group 2 were evaluated with corneal topography and Pentacam tomography. The eye with the lowest average corneal power (ACP) was recruited in group 2. Pentacam reported indices for the anterior corneal surface (ISV, IVA, KI, CKI, IHA, IHD and Rmin), relative pachymetric progression from thinnest point at 1, 2, 3, 4 and 5-mm (RelProg1-5), maximum posterior elevation (PElev), Belin’s adjusted posterior elevation (PElevBelin) and normalized Belin-Ambrosio indices (Df, Db, Dp, Dt, Dy and overall D) were compared between groups. Diagnostic capacity was determined by receiver-operating characteristic (ROC) analysis.

Results: : The two groups were not significantly different in mean age (years, 32.8±13.0 vs 31.5±12.3), central corneal thickness (µm, 510.1±26.9 vs 498.8±34.8) or ACP (diopters, 44.02±1.82 vs 44.58±2.21). All but one anterior corneal surface indices were significantly different (p<0.05, Student’s t test) in group 2 eyes. Relative pachymetric progression was significantly greater in group 2 eyes up to 4 mm from the thinnest point (p<0.05, Student’s t test). PElev and PElevBelin, Df, Db, Dp and overall D, but not Dt and Dy, were significantly higher in group 2 eyes (p<0.05, Student’s t test). The highest areas under the ROC curve were those of D (0.851), ElevPMax (0.842), Dp (0.836), ElevPMaxBelin (0.830) and Db (0.806). Optimum cutoff values for ElevPMax and ElevPMaxBelin were >9 µm and >12 µm, respectively, with 81% sensitivity and 82% specificity in both cases.

Conclusions: : Pentacam indices describing posterior corneal elevation and pachymetric progression can correctly identify a high proportion (about 80%) of subclinical keratoconus eyes with insufficient anterior topography findings.

Keywords: keratoconus • cornea: clinical science • refractive surgery: other technologies 
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