March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Keratoconus Match Index of normal and keratoconus suspect eyes
Author Affiliations & Notes
  • Maxime Delbarre
    Department of Ophthalmology, Percy Military Hospital, Clamart, France
  • Mikhael Lussato
    Department of Ophthalmology, Percy Military Hospital, Clamart, France
  • Catherine Verret
    Military Department of Epidemiology and Public Health, Saint Mandé, France
  • Bénédicte Blavier
    Department of Ophthalmology, Percy Military Hospital, Clamart, France
  • Corinne Leduc
    Department of Ophthalmology, Percy Military Hospital, Clamart, France
  • Pascale Crepy
    Department of Ophthalmology, Percy Military Hospital, Clamart, France
  • Françoise Froussart-Maille
    Department of Ophthalmology, Percy Military Hospital, Clamart, France
  • Jean Claude Rigal-Sastourné
    Department of Ophthalmology, Percy Military Hospital, Clamart, France
    Military Department of Epidemiology and Public Health, Saint Mandé, France
  • Footnotes
    Commercial Relationships  Maxime Delbarre, None; Mikhael Lussato, None; Catherine Verret, None; Bénédicte Blavier, None; Corinne Leduc, None; Pascale Crepy, None; Françoise Froussart-Maille, None; Jean Claude Rigal-Sastourné, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1118. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Maxime Delbarre, Mikhael Lussato, Catherine Verret, Bénédicte Blavier, Corinne Leduc, Pascale Crepy, Françoise Froussart-Maille, Jean Claude Rigal-Sastourné; Keratoconus Match Index of normal and keratoconus suspect eyes. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1118.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To compare Keratoconus Match Index (KMI) of the Ocular Response Analyser between keratoconus, forme fruste keratoconus and normal corneas and estimate the sensitivity and the specificity of KMI in discriminating forme fruste keratoconus from healthy corneas.

Methods: : The study population of this retrospective comparative case series was divided into 3 groups: 24 keratoconic (KCN) eyes (16 patients), 8 forme fruste keratoconic eyes (FFKCN, normal topography with controlateral KC), and 36 healthy eyes (18 patients). Every patient underwent a complete clinical eye examination, a corneal topography, and a biomechanical evaluation with the Ocular Response Analyser (ORA; Reichert Ophthalmic Instruments, Buffalo, NY, USA). Corneal hysteresis (CH), corneal resistance factor (CRF), and KMI were compared between the 3 groups. The receiver operating characteristic (ROC) curve was used to identify cutoff points that maximized sensitivity and specificity in discriminating FFKCN from normal corneas.

Results: : The mean KMI was 0.20 for KCN, 0.67 for FFKCN and 0.928 for control eyes. There was a statistically significant difference between the 3 groups (P < 0.001) and also between the FFKCN group and the control group (P = 0.05). The mean CH was 7.31 mmHg for KCN, 9.21 mmHg for FFKCN and 10.8 mmHg for control eyes (P < 0.001). The mean CRF was 6.29 mmHg for KCN, 8.18 mmHg for FFKCN and 10.6 mmHg for control eyes (P < 0.001). For a threshold of 0,8, KMI had a sensitivity of 63% with a specificity of 72%. For a threshold of 10,7mmHg, the CH had a sensitivity of 75% and a specificity of 66,7%.

Conclusions: : There is a significant difference in the mean KMI between normal and FFKCN corneas. Sensitivity and specificity of this index are not greater than those of CH and CRF. KMI seems to be useful for the detection of FFKCN but further studies with bigger samples are necessary.

Keywords: keratoconus 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×