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Vikas Tah, Javier Zarranz-Ventura, Dawn A. Sim, Pearse A. Keane, Catherine A. Egan, Praveen J. Patel, Richard W. Lee, Adnan Tufail, Carlos E. Pavesio, Mark C. Westcott; Characterization of Choroidal Structure in Sympathetic Ophthalmia using Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1156.
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Characterization of choroidal structure in sympathetic ophthalmia using optical coherence tomography
Images were retrospectively collected from patients with known sympathetic granulomatous panuveitis. Data regarding disease activity of the sympathizing eye, treatment, and type of injury to the exciting eye was obtained from electronic patient records.
Five eyes from five patients were included in the analysis. The male to female ratio was 3:2. There were 3 Caucasian and 2 African patients. Mean age was 49.6 years (Range 21-72). 4 patients had previous ennucleations, and 1 had a phthsical eye. All patients suffered from traumatic penetrating injuries. Time from injury to the exciting eye ranged from 8 years to 56 years. 2 patients had active disease, 3 were quiescent. Four patients were on oral steroids at the time of image acquisition. Generalized choroidal atrophic changes on EDI OCT were observed in all cases. There was a loss of choroidal vascularity as compared to normal controls, with increased diffuse interstitial signal between choroidal vessels in Haller’s large vessel layer observed in both active and quiescent disease states.
Histological features of sympathetic ophthalmia classically describe a thickened posterior choroid secondary to inflammatory infiltration. We have conversely observed a thinned atrophic choroid in these patients, irrespective of disease activity. Increased signal within the choroidal vessels may represent scarring or inflammatory cellular infiltrate.
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