March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Spectral-Domain Optical Coherence Tomography Findings in Polypoidal Choroidal Vasculopathy: The Polyps are Anterior to Bruch Membrane
Author Affiliations & Notes
  • Nicola G. Ghazi
    Vitreo/Retinal (KKESH), King Khaled Eye Specialist Hosp, Riyadh, Saudi Arabia
  • Hanan Al Shamsi
    Vitreo/Retinal (KKESH), King Khaled Eye Specialist Hosp, Riyadh, Saudi Arabia
  • Eman Al Kahtani
    Vitreo/Retinal (KKESH), King Khaled Eye Specialist Hosp, Riyadh, Saudi Arabia
  • Footnotes
    Commercial Relationships  Nicola G. Ghazi, None; Hanan Al Shamsi, None; Eman Al Kahtani, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1168. doi:
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    • Get Citation

      Nicola G. Ghazi, Hanan Al Shamsi, Eman Al Kahtani; Spectral-Domain Optical Coherence Tomography Findings in Polypoidal Choroidal Vasculopathy: The Polyps are Anterior to Bruch Membrane. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1168.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

to report spectral domain optical coherence tomography (SD-OCT) findings in polypoidal choroidal vasculopathy (PCV)

 
Methods:
 

Ten eyes of 10 consecutive patients were diagnosed with PCV based on typical clinical and angiographic findings including indocyanine green angiography. All eyes were also imaged with macular SD-OCT including line scans passing through the polyps.

 
Results:
 

SD-OCT findings included typical and atypical retinal pigment epithelial (RPE) detachments (PED) and subretinal and intraretinal fluid in all eyes. In addition in the areas corresponding to the polyps, well-delineated round-oval, sub-RPE cavities with low to medium reflectivity centrally and hyperreflective borders were noted within the space of an atypical PED. The cavities were adherent to the posterior surface of the detached RPE way above the subjacent Bruch membrane, and the RPE appeared to be draped over them. No retinal or choroidal connections to the cavities were noted.

 
Conclusions:
 

These findings suggest that the polyps in PCV are not located in the inner choroid, but rather in the sub-RPE space, anterior to Bruch membrane. The close proximity of the polyps to the RPE and the configuration of the RPE around the polyps may shed light on the pathogenesis of PCV and may also contribute to the relatively good prognosis of PCV compared to typical choroidal neovascularization.

 
Keywords: imaging/image analysis: clinical • age-related macular degeneration • choroid: neovascularization 
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