Purchase this article with an account.
Lola E. Lawuyi, Pearse A. Keane, Javier Z. Ventura, Dawn A. Sim, Catherine A. Egan, Praveen J. Patel, Mark Westcott, Richard W. Lee, Adnan Tufail, Carlos Pavesio; Structural Changes of the Choroid in Sarcoid-Related Granulomatous Panuveitis. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1194.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To characterize retinal and choroidal structure in the maculae of patients with sarcoid-related panuveitis using spectral domain optical coherence tomography (OCT).
Patients with a known diagnosis of sarcoid-related granulomatous panuveitis were scanned using custom enhanced depth imaging (EDI) protocols (Spectralis, Heidelberg Engineering, Germany). Each image set consisted of seven OCT B-scans obtained in a 20 x 15 degree horizontal raster pattern, and with each individual B-scan generated from 50 averaged scans. Manual segmentation of retinal and choroidal layers (including Haller’s large vessel and Sattler’s medium vessel layers) was then performed using custom image analysis software. Visual acuity (VA), disease activity, and treatment modality were correlated with OCT findings.
Thirteen eyes from thirteen subjects were evaluated. Mean patient age was 51.6 years (range: 31-70), with a male : female ratio of 9:4. There were six Asian-Indian, six Afro-Caribbean, and one undeclared subject. At the time of scanning, six patients required treatment with oral steroid or steroid-sparing agents, while seven patients were treated solely with topical steroids. Five subjects had active disease, while eight were quiescent. Mean VA was 95.8 +/- 5.72 EDTRS letters. Mean retinal thickness was 281.7 mm, mean retinal volume 9.83 mm3, mean choroidal thickness 300.6 mm, and mean choroidal volume 10.5 mm3. Mean volume of Haller’s layer was 4.2mm3. An increased ratio of Haller’s layer to the choroid as a whole was significantly associated with reduced VA (r = 0.76, p = 0.004) in all patients.
Evaluation of choroidal structure using specialized OCT scanning protocols may provide new insights into diffuse granulomatous uveitic disorders such as sarcoidosis, with changes in Haller’s layer providing clinically useful information about diagnosis and treatment monitoring.
This PDF is available to Subscribers Only