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Andrew Scott, Javier Zarranz-Ventura, Pearse A. Keane, Dawn A Sim, Catherine Egan, Praveen J Patel, Richard W. Lee, Adnan Tufail, Carlos Pavesio, Mark Westcott; Reduction of Visual Acuity in Idiopathic Panuveitis is Associated with Thinning of Sattler’s Medium Vessel Layer of the Choroid. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1197.
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© ARVO (1962-2015); The Authors (2016-present)
To characterize chorioretinal changes in the maculae of patients with idiopathic panuveitis using enhanced depth imaging (EDI) optical coherence tomography (OCT).
Data from Spectral domain EDI OCT images (Spectralis, Heidelberg Engineering, Germany) were retrospectively collected from patients diagnosed with idiopathic panuveitis. Images were obtained using custom EDI scanning protocols (each image set consisted of 7 OCT B-scans obtained in a 20 x 15 degree horizontal raster pattern, and with each individual B-scan generated from 50 averaged scans). Quantitative segmentation of the retina and choroidal layer was performed for each case. The choroidal layer was further segmented into Haller’s large vessel and Sattler’s medium vessel layers. Visual acuity was correlated with OCT findings using Spearman’s rank correlation coefficient.
Eight eyes from eight subjects with quiescent idiopathic panuveitis were evaluated. Qualitative analysis showed thinning the choroid, in particular Sattler’s medium vessel layer. EDI OCTs showed a mean retina thickness of 406.4 +/- 63.2 mm, and mean choroidal thickness of 252.0 +/- 50.5 mm. The ratio of retinal:choroidal thickness in the total scanned area was strongly correlated with visual acuity (r=-0.862, p=0.006), as was retinal:choroidal intensity (r=0.946, p=0.0004). Total choroidal:Haller’s layer thickness ratios were not significantly correlated with visual acuity in the whole scan area (r=0.587, p=0.126), but correlated in the foveal region (EDTRS area 9) (r=0.707, p=0.05). Total choroidal:Haller’s layer intensity ratios were significantly correlated in both total scan area as well as in the fovea (r=0.874, p=0.004) (r=0.826, p=0.01).
EDI OCT of patients with idiopathic panuveitis showed thinning of the choroid, in particular, Sattler’s medium vessel layer. This strongly correlated with visual acuity, particularly in the foveal region.
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