March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Clinical Features And Frequency Of Various Types Of 103 Consecutive Ocular Adnexal Lymphoma In A Tertiary Referral Center
Author Affiliations & Notes
  • mathieu ZMUDA
    Ophthalmology,
    Fondation ophtalmologique Rothschild, PARIS, France
  • blandine LANGLOIS
    Ophthalmology,
    Fondation ophtalmologique Rothschild, PARIS, France
  • marc PUTTERMAN
    Pathology,
    Fondation ophtalmologique Rothschild, PARIS, France
  • pierre-vincent JACOMET
    Ophthalmology,
    Fondation ophtalmologique Rothschild, PARIS, France
  • serge MORAX
    Ophthalmology,
    Fondation ophtalmologique Rothschild, PARIS, France
  • olivier GALATOIRE
    Ophthalmology,
    Fondation ophtalmologique Rothschild, PARIS, France
  • Footnotes
    Commercial Relationships  mathieu Zmuda, None; blandine Langlois, None; marc Putterman, None; pierre-vincent Jacomet, None; serge Morax, None; olivier Galatoire, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1259. doi:
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      mathieu ZMUDA, blandine LANGLOIS, marc PUTTERMAN, pierre-vincent JACOMET, serge MORAX, olivier GALATOIRE; Clinical Features And Frequency Of Various Types Of 103 Consecutive Ocular Adnexal Lymphoma In A Tertiary Referral Center. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1259.

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Abstract

Purpose: : The aim of this study is to evaluate the clinical features and frequency of various types of ocular adnexal lymphoma (OAL) biopsy-proven seen in a tertiary referral center.

Methods: : A retrospective study of 103 consecutive OAL seen at a single institution in a tertiary referral center from January 2004 to December 2011. Each lesion was documented by CT and/or MRI, and in all cases the diagnosis was established with a surgical biopsy.

Results: : The study included 46 men and 57 women, sex ratio(F/M) was 1.23, mean age 65.6 years range[25-96] at diagnosis. Follow-up ranged from 3 to 84 months (median, 60.5 months). The first symptom was swelling (eyelid, conjunctiva, lacrimal gland) in 37 cases , proptosis (22), ptosis (20), diplopia (12), epiphora (5), chemosis (4), loss of visual acuity (3). 18 patients had knowned hemopathy (12 lymphoma, 3 chronic lymphatic leukemia, 3 Waldenstrom macroglobulinemia), infectious diseases associated were B hepatitis (3), C hepatitis (1), HIV (1), and immunologic pathology were Sjögren (3), Lupus (1), rheumatoid arthritis (1). By using CT or MRI the tumors were localized in orbit (89), only conjunctiva (5), only eyelid (9). The tumors affected the anterior orbit in 92 patients, the medium orbit in 33 patients and one patient had an apical lesion. The superior-temporal quadrant was the most affected in 68 cases, superior-nasal, 33 in inferior-temporal and 12 in inferior-nasal. Lesions was bilateral in 18 patients. The main type of lymphoma was MALT (66), then follicular lymphoma (12), lymphoplasmacytic lymphoma (9), lymphocytic lymphoma (6), mantle cell lymphoma (5), large cell lymphoma (2), burkitt lymphoma (1), plasmablastic lymphoma (1), cutaneous T cell lymphoma (1).

Conclusions: : The OAL are mostly extranodal low grade B-cell lymphoma of the MALT type, unilateral, located at the anterior part of the orbit, next to the lacrimal gland, and it is the initial lesion of hemopathy in 84% of cases.

Keywords: orbit • pathology: human • oncology 
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