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Elena Garcia-Martin, Isabel Pinilla, Eva Sancho, Miriam Idoipe, Pilar Calvo, Isabel Fuertes, Emilio Abecia; Fourier-domain Optical Coherence Tomographies In Macular Holes Eyes: Reproducibility And Ability To Detect Retinal Changes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1021.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the ability of Fourier-domain (FD) optical coherence tomography (OCT) to detect retinal changes in macular holes (MH) eyes. To test the intra-session reproducibility of macular thickness measurements in MH and healthy subjects using Cirrus and Spectralis OCT.
Eighty of 80 subjects (40 MH patients and 40 healthy subjects) underwent three macular scans by the same experienced examiner using the Cirrus and Spectralis OCT instruments. Differences between healthy and MH eyes were compared. The relationship between average thicknesses with each OCT was evaluated. Repeatability was studied by intra-class correlation coefficients and coefficients of variation (COV) for the nine areas corresponding to the Early Treatment Diabetic Retinopathy Study.
Macular thickness increase was detected in MH eyes for all OCT parameters (p<0.05). Macular average thickness was 325.92±84.9 and 352.90±67.0 µm in MH eyes using Cirrus and Spectralis, respectively. Healthy subjects showed 268.49 ± 21.8 and 277.47 ± 18.9 µm measuring the same parameters. Morphologic changes in retinal layers were detected using both OCTs. Macular average thickness in MH eyes as determined by both OCTs was correlated (r= 0.636; p<0.045), but differences were significant (p=0.009). In MH eyes, measurements showed a mean COV of 4.1% using Cirrus and 4.7% using Spectralis while healthy subjects showed COV of 1.4 and 0.6 % using Cirrus and Spectralis respectively. Intra-class correlation coefficients were higher than 0.856 in MH eyes and higher than 0.919 in healthy eyes.
Macular thickness measurements in MH and healthy eyes, show significant differences between Cirrus and Spectralis despite the correlation of measurement between the two instruments. Fourier-domain OCT can be considered a valid device to detect alterations in MH patients.
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