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Torcato Santos, Ana Santos, Rui Bernardes, Jose G. Cunha-Vaz; Poor Correlation Between PHP Measurements and Development of Choroidal Neovascularization in AMD Patients. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1053.
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To establish relations between changes detected with preferential hyperacuity perimetry (PHP) and the high risk of development of choroidal neo-vasculature (CNV) in a series of eyes with dry AMD.
Forty-one fellow eyes from 41 patients with unilateral exudative AMD, aged 61 to 93 (mean ± SD: 77.27 ± 6.75 yrs), 14 male and 27 female, were followed with a complete ophthalmological examination, including fluorescein angiography for the identification CNV development, every 6-months for a period of 2 years. Patients underwent PHP (Reichert Inc., Depew, NY, USA) and macular retinal thickness (RT) by OCT measurements using the HRA-Spectralis (Heidelberg Engineering, Heidelberg, Germany). Maps of hyperacuity deviation were created and processed to compute areas of alteration (%), level of deviation and distance to the fovea. Two patients/eyes were excluded due to unreliable PHP test. Maps of RT were equally created using the ETDRS grid chart. Both maps were co-registered to allow establishing co-relations between PHP and RT deviations from a healthy reference population.
Three of the 39 eyes converted from dry to wet AMD during the study period. From the 36 non converter eyes, 31 (86.1%) presented PHP alterations, while only 5 out of 36 eyes (13.9%) did not present any alteration in PHP. For the 3 eyes that developed CNV, 2 eyes exhibited alterations in the PHP map before conversion and one did not present any alteration before conversion. No correlations were found between RT and the percentage of PHP deviation area.
No clear correlation could be found between PHP and the progression from dry to wet AMD. PHP alterations were found in 86.1% of fellow eyes with dry AMD and in the 3 eyes that developed CNV one of them did not display any alterations on the PHP map.No correlation was found between changes in macular RT based on HRA-Spectralis OCT and PHP in this set of AMD patients fellow eyes.
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