March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Comparison of Quality of Vision after Wavefront-Guided and Wavefront-Optimized LASIK
Author Affiliations & Notes
  • Myung S. Ko
    Ophthalmology, Stanford University School of Medicine, Stanford, California
  • Edward E. Manche
    Ophthalmology, Stanford Univ Sch of Med, Palo Alto, California
  • Footnotes
    Commercial Relationships  Myung S. Ko, None; Edward E. Manche, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1483. doi:
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      Myung S. Ko, Edward E. Manche; Comparison of Quality of Vision after Wavefront-Guided and Wavefront-Optimized LASIK. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1483.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To compare the effect of wavefront-guided and wavefront-optimized LASIK by ALCON system on patients’ perceived quality of vision.

Methods: : 36 patients (72 eyes) were enrolled in this prospective study to undergo LASIK surgery using the Alcon Wavelight Allegretto Wave Eye-Q 400 Hz excimer laser system. One eye was randomized to undergo wavefront-guided LASIK and the fellow eye to wavefront-optimized LASIK. Patients answered questionnaires on their visual symptoms and quality of vision preoperatively and at one, three, and six months after surgery. A paired t-test was used to compare symptom severity between the two treated eyes and also between pre- and post-operative symptoms.

Results: : Eyes in both groups experienced significantly more glare and haze frequency after 1 month (p=0.001- 0.036), but these symptoms were no longer significant at 6 months postoperatively (p=0.407-0.940). No significant changes in frequency of halos, clarity, double vision, or ghost images occurred in either group at both 3 months and 6 months post-operatively. Eyes in both groups experienced significantly improved vision at 3 and 6 months postoperatively (p <0.001 - 0.013). Of the 31 patients who self-evaluated their overall vision, 32.3% (n=10) reported better vision in the eye receiving wavefront-guided LASIK, 25.8% (n=8) reported better vision in the eye receiving wavefront-optimized LASIK, and 41.9% (n=13) reported no subjective difference in vision between the two eyes. These differences were not statistically significant (p=0.542).

Conclusions: : Six months after surgery, patient self-reported visual symptoms were not significantly different in eyes receiving wavefront-guided or wavefront-optimized LASIK by the ALCON system. These symptoms were consistent with the patients’ self-evaluation of their overall vision, which revealed no difference between the two groups. Future evaluations will be performed on this patient cohort at 12 months post-operatively to further evaluate the visual symptoms.

Clinical Trial: : NCT01138189

Keywords: refractive surgery: LASIK • refractive surgery: comparative studies • refractive surgery 

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