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Anne Petersen, Dragana Celojevic, Gunnar Tasa, Madeleine Zetterberg; Association Study Of Cu-Zn Superoxide Dismutase Genes In Age-related Cataract. Invest. Ophthalmol. Vis. Sci. 2011;52(14):812. doi: https://doi.org/.
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Copper-zinc superoxide dismutases, SOD1 and SOD3, are both enzymes involved in the protection against oxidative stress, in the cytosol and extracellular space respectively. Polymorphisms of their encoding genes have been associated with various age-related diseases. This study reports different single nucleotide polymorphisms of SOD1 and SOD3 in Estonian patients with age-related cataract.
TaqMan SNP genotyping assays for polymorphisms in SOD1 (rs17881180, rs17880135, rs2234694) and SOD3 (rs1799895, rs2536512) were used to genotype cataract patients (N=492) and controls (n=186). The cataract group was divided into different subtypes; cortical (n=151), nuclear (n=75), posterior subcapsular (n=119) and mixed (n=147) cataract. Statistical analyses for SNP associations were performed using Χ2-test and binary logistic regression including relevant covariates (age, sex, smoking habits, genotypes and cataract subtypes).
Genotype frequencies for the cataract and the control groups were similar to reported frequencies in other populations for all investigated SNPs. No significant associations were seen between the cataract and the control groups using univariate or multivariate analyses. Stratifying the data with regard to type of cataract did not reveal any associations with the analysed SNPs of SOD1 or SOD3. Current smoking was associated with cataract diagnosis in the logistic regression (P<0.05).
Polymorphisms of the SOD1 or SOD3 genes are not associated with diagnosis of cataract, indicating that other antioxidative enzymes may be more important in protecting the lens from oxidative stress.
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