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Shinichi Otani, Taiji Nagaoka, Eiichi Sato, Atsushi Takahashi, Kenji Sogawa, Seigo Nakabayashi, Tomofumi Tani, Akitoshi Yoshida, III; Association Between Body Mass Index And Retinal Circulation In Patients With Type 2 Diabetes Mellitus. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1274.
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© ARVO (1962-2015); The Authors (2016-present)
To study the relationship between body mass index (BMI) and retinal circulation in patients with type 2 diabetes mellitus.
Four hundred ninety-four patients (273 men, 221 women) with type 2 diabetes with no or early-stage diabetic retinopathy were enrolled in this study. The patients were divided into three groups according to BMI based on the International Classification of the World Health Organization (normal, <25 kg/m2; overweight, 25-30 kg/m2, and obese, >30 kg/m2). Using a laser Doppler velocimetry system (CLBF Model 100; Canon, Tokyo, Japan), the retinal vessel diameter and blood velocity were measured and the retinal blood flow (RBF) was calculated. The data were assessed using one-way analysis of variance followed by the Tukey-Kramer post hoc comparison.
In women, the RBF (p=0.0353) significantly decreased in the overweight group compared with the normal group. In contrast, there was no difference in RBF among the groups of men.
Our results indicated that the RBF decreased in women with type 2 diabetes in the overweight group, suggesting that the degree of obesity may be associated with impaired retinal circulation in women with type 2 diabetes.
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