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Mariacristina Parravano, Francesco Oddone, Barbara Boccassini, Paola Giorno, Francesca Berardo, Patrizia Borboni, Monica Varano; The Role of Humphrey Matrix Testing in the Long Term Follow Up of Type 1 Diabetes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1289.
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to investigate the role of frequency doubling perimetry (Humphrey Matrix; Carl Zeiss Meditec Inc., Dublin, CA, USA) in the long term follow up in subjects with type 1 diabetes mellitus (DM1) without any signs of retinal vasculopathy, and to investigate the relationship between both functional and structural retinal parameters and metabolic control.
consecutive subjects with DM1, with no sign of retinal vasculopathy at baseline, have been followed for long term in this prospective cross-sectional clinical study. Functional testing included Humphrey Matrix perimetry (30-2 threshold program) and white-on-white Humphrey visual field perimetry (HFA, 30-2 SITA standard), while retinal nerve fibre layer (RNFL) thickness was measured by scanning laser polarimetry with variable corneal birefringence compensator (GDx VCC).
data from 19 eyes of 19 subjects with DM1 (age 39,5±9,2; 10 males/9 females) were analyzed. Mean follow up time was 59,2±5,4 months (range 49-65). Mean diabetes duration was 17,4±13 years. Mean HbA1c was 7,42±1,22%. 10/19 patients used insulin microinfusor. Only one patient showed a progression to non proliferative diabetic retinopathy during the follow up. Similar values were found between baseline and the end of follow up both for HFA mean deviation (MD: -2,20±3,44 vs -1,63±2,47; p=0,14) and pattern standard mean deviation (PSD: 2,50±1,71 vs 2,28±1,36; p=0,31). Matrix MD was found to be similar between baseline and the end of follow up (-1,06±3,62 vs -1,24±2,99; p=0,65). A statistically significant difference was found for Matrix PSD between baseline and the end of follow up (2.76±0.59 vs 3.1±0.68; p= 0.0078). Morphological parameters were not changed during follow up. A significant relationship was found between HbA1c levels and changes from baseline of Matrix PSD (R2 0,29, p=0.02).
the localized reduction of retinal sensitivity, as measured by Matrix, seem to be the only parameter that showed a significant change during long term follow up in our population of DM1 patients.
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