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Sarah Van de Velde, Tine Van Bergen, Evelien Vandewalle, Davine Sijnave, Karolien Hollanders, Lieve K. Moons, Dirk Leysen, Ingeborg Stalmans; Intra Ocular Pressure Lowering Efficacy of AMA0076, a Locally Acting Rho Kinase (ROCK) Inhibitor, in Dutch Belted Rabbits. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1977.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the intra ocular pressure (IOP) lowering efficacy of the local ROCK inhibitor, AMA0076, in Dutch Belted rabbits.
Dutch Belted rabbits (5 rabbits/group) received topically a single dose of AMA0076 in one eye. A concentration range of 0.031 - 0.625% AMA0076 was tested. The contralateral eye served as control and was treated with saline. IOP was measured at baseline and 30 min, 1, 2, 3, 4, 5, 6, 7 and 8h post topical administration.
Single topical administration of AMA0076 significantly lowered IOP in all groups compared to the control eye (p<0.05). Mean baseline IOP during the experiments was between 20.6 and 21.5 mmHg. Thirty minutes after topical treatment, a concentration dependent reduction in IOP was demonstrated with a ΔIOP ranging from 3.9mmHg - 7mmHg compared to the control eye. Maximal IOP reduction of each concentration following single dose administration of AMA0076 was observed ±2 hours after instillation with a ΔIOP ranging from 4.6mmHg and 7.5mmHg. The IOP lowering effect with the highest concentrations of AMA0076 (0.625% and 0.125%) was sustained during the experiment.
AMA0076 was effective in rapidly lowering IOP in a dose depended and sustained manner after a single topical dose in Dutch Belted rabbits. This new class of local ROCK inhibitors has potential therapeutic value for the IOP lowering treatment of glaucoma.
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