March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Adaptive Optics Imaging of Geographic Atrophy
Author Affiliations & Notes
  • Kiyoko Nakashima
    CIC 503, INSERM, Quinze-Vingts Natl Eye Hosp, Paris, France
  • Martine Ullern
    CIC 503, INSERM, Quinze-Vingts Natl Eye Hosp, Paris, France
  • Mustapha Benchaboune
    CIC 503, INSERM, Quinze-Vingts Natl Eye Hosp, Paris, France
  • Jose-Alain Sahel
    CIC 503, INSERM, Quinze-Vingts Natl Eye Hosp, Paris, France
  • Michel Paques
    CIC 503, INSERM, Quinze-Vingts Natl Eye Hosp, Paris, France
  • Footnotes
    Commercial Relationships  Kiyoko Nakashima, None; Martine Ullern, None; Mustapha Benchaboune, None; Jose-Alain Sahel, None; Michel Paques, None
  • Footnotes
    Support  French National Research Agency (ANR) through Tecsan Program (project iPhot, ANR-09-TECS-009)
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2052. doi:
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    • Get Citation

      Kiyoko Nakashima, Martine Ullern, Mustapha Benchaboune, Jose-Alain Sahel, Michel Paques; Adaptive Optics Imaging of Geographic Atrophy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2052.

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Abstract
 
Purpose:
 

To report the findings of en face adaptive optics (AO) fundus flood imaging in eyes with geographic atrophy(GA).

 
Methods:
 

Eight eyes of eight patients with GA underwent 850nm AO imaging (rtx1, Imagine Eyes, France) of the macula. Results were compared to reflectance and autofluorescence scanning laser ophthalmoscope imaging and to optical coherence tomography. Disease progression was documented over successive examinations.

 
Results:
 

Compared to the other imaging modalities, AO allowed a better delineation of GA limits and showed more details about melanin redistribution within and around GA areas. Disseminated melanin clumps gave a diffuse salt and pepper appearance to all GA areas, independently of their size; such clumps were also detected outside of GA areas. On the retina bordering atrophic areas, focal or diffuse melanin accumulation at the level of the RPE colocalized with 488nm hyperautofluorescence. During follow-up (n=2 eyes), extension of GA areas was associated to melanin redistribution within and outside GA areas.

 
Conclusions:
 

AO imaging allows a fine characterization of lesional extension and progression, in particular because of the precise mapping of the redistribution of melanin-like pigments. The latter is a dynamic process that may either reflect the disease activity or indicate a post-degenerative process. Therefore AO imaging may provide novel biomarkers for detecting the earliest stages, documenting the retinal pathology and monitoring progression of GA.

 
Keywords: age-related macular degeneration • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retinal pigment epithelium 
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