March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Features Associated with Progression of Geographic Atrophy (GA) from Autofluorescence (AF) Images
Author Affiliations & Notes
  • Amitha Domalpally
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • Ronald P. Danis
    Ophthal & Vis Sciences,
    Univ of Wisconsin-Madison, Madison, Wisconsin
  • Ashwini Narkar
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • Barbara A. Blodi
    Ophthalmology,
    Univ of Wisconsin-Madison, Madison, Wisconsin
  • Emily Y. Chew
    Epidemiology & Clinical Applications, National Eye Inst/NIH, Bethesda, Maryland
  • Traci E. Clemons
    Statistics, Emmes Corporation, Rockville, Maryland
  • AREDS2 Research Group
    Ophthalmology, Fundus Photograph Reading Center, Madison, Wisconsin
  • Footnotes
    Commercial Relationships  Amitha Domalpally, None; Ronald P. Danis, None; Ashwini Narkar, None; Barbara A. Blodi, None; Emily Y. Chew, None; Traci E. Clemons, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2053. doi:
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      Amitha Domalpally, Ronald P. Danis, Ashwini Narkar, Barbara A. Blodi, Emily Y. Chew, Traci E. Clemons, AREDS2 Research Group; Features Associated with Progression of Geographic Atrophy (GA) from Autofluorescence (AF) Images. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2053.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To evaluate the features associated with progression of GA from AF images

 
Methods:
 

AF images (from scanning laser ophthalmoscopy) images are captured at annual visits in the Age Related Eye Disease Study 2 (AREDS2) ancillary study. Eyes with GA and two years of follow-up were evaluated for center involvement, configuration (unifocal or multifocal),presence of halo and background AF(changes outside the grid; see figure). The area of GA and the area of AF abnormalities surrounding GA within the grid(as shown by the dotted lines in the figure) were measured using planimetry. The presence of GA on corresponding color photos was also evaluated.

 
Results:
 

AF images of 156 eyes with GA at baseline and two year follow-up were evaluated. The mean baseline area of GA from AF images was 3.57 mm2 (SD 5.24; median 1.19 mm2), with 54% of lesions multifocal. The mean progression rate/year was 1.41mm2 (SD 1.65) and on the square root scale 0.68mm (SD 0.65). The baseline measurements did not correlate with progression rate both with area (r 0.1, p0.18) and square root measurements(r-0.1, p0.19). The baseline area of abnormal AF surrounding GA correlated with progression rate (r = 0.3, p<0.001). Of the categorical features evaluated, the presence of halo (p=0.06) and presence of background AF changes (p=0.04) had significant correlation with progression rate.

 
Conclusions:
 

Area of abnormal AF surrounding the GA, presence of halo and changes in background AF are associated with a more rapid progression of GA on AF.  

 
Clinical Trial:
 

http://www.clinicaltrials.gov NCT00345176

 
Keywords: age-related macular degeneration • imaging/image analysis: clinical • retina 
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