March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Predictive Value Of Retinal Nerve Fiber Layer Thickness Measured By Optical Coherence Tomography On Visual Recovery In Dysthiroid Optic Neuropathy After Decompression Surgery
Author Affiliations & Notes
  • Francisco J. Munoz Negrete
    Ophthalmology, Hospital Ramon y Cajal IRYCIS, Madrid, Spain
  • Marta Pérez-López
    Ophthalmology, Hospital Ramon y Cajal IRYCIS, Madrid, Spain
  • Gema Rebolleda
    Ophthalmology, Hospital Ramon y Cajal IRYCIS, Madrid, Spain
  • Marco Sales-Sanz
    Ophthalmology, Hospital Ramon y Cajal IRYCIS, Madrid, Spain
  • Pilar Casas de Llera
    Ophthalmology, VISSUM, Alicante, Spain
  • Footnotes
    Commercial Relationships  Francisco J. Munoz Negrete, None; Marta Pérez-López, None; Gema Rebolleda, None; Marco Sales-Sanz, None; Pilar Casas de Llera, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2096. doi:
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      Francisco J. Munoz Negrete, Marta Pérez-López, Gema Rebolleda, Marco Sales-Sanz, Pilar Casas de Llera; Predictive Value Of Retinal Nerve Fiber Layer Thickness Measured By Optical Coherence Tomography On Visual Recovery In Dysthiroid Optic Neuropathy After Decompression Surgery. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2096.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine whether in vivo retinal nerve fibre layer (RNFL) thickness measurements predict visual recovery after orbital bone decompression surgery in patients with dysthiroid optic neuropathy (DON) and visual field defects.

Methods: : 28 eyes of 15 patients undergoing orbital bone decompression surgery for Graves' orbitopathy were prospectively assessed before orbital decompression and one month after surgery with a neuro-ophthalmic examination, involving standard automated visual field (VF) testing and by spectral domain optical coherence tomography (OCT) measurements of RNFL thickness (Cirrus OCT).

Results: : Only in 5 eyes (17,5%) DON was diagnosed. All of them had preoperative VF defects (median mean deviation -MD- was -8,00 dB and median pattern standard deviation -PSD- was 6,06 dB). In 4 eyes preoperative RNFL average thickness was normal and in 1 eye RNFL average thickness was significantly thinned. After decompression surgery, eyes with preoperative normal RNFL thickness showed improvement in MD (-10,05 dB and -4,90 dB before and after surgery respectively p=0,068) and in PSD (5,65 dB before surgery and 2,56 dB after surgery p=0,06) unlike the only eye with abnormally thin preoperative RNFL thickness, which had no improvement in visual field index.

Conclusions: : Normal baseline RNFL thickness measured with OCT in eyes with dysthiroid optic neuropathy despite VF defects may predict an improvement in visual outcome after treatment.

Keywords: nerve fiber layer • optic nerve • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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