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Roberta Giannini, Simona Altimari, Luigi Zompatori; How appropriate is the indication of Spectral - Domain Optical Coherence Tomography (SD-OCT) and Electroretinography (ERG) in early diagnosis of cloroquine or hydroxychloroquine ocular toxicity. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2099.
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To examine if SD-OCT imaging is giving some more information than multifocal ERG about retinal toxicity in a group of 25 patients in long term treatment with hydoxychloroquine.
SD-OCT and multifocal ERG (Retinoscan) in 25 patients (50 eyes) after 5 years of hydroxychloroquine treatment were examined. In all of them a complete ophtalmological examination was performed. The entry criteria in both groups were BCVA 0.67 and better and negative Amsler grid test.
No significant changes in OCT images were observed in 13 patients (22 eyes) with negative multifocal ERG. Small Retinal Pigment Epithelium (EPR) changes were observed in only 7 patients (10 eyes) of the 12 patients (22 eyes) with multifocal ERG abnormalities.
The correlation between OCT and multifocal ERG were statistically observed even if multifocal ERG seems to be a prognostic method more sensitive and relevant to find morfological and functional alterations from the beginning in patients with long term treatment with hydrochloroquine.
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