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Daniela A. Toscano, Marcos P. Ávila, Rodrigo A. Santos, Maria Regina C. Chalita; Reproducibility of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain OCT in Brazilian Patients. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2103.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness measurements in eyes without and with glaucoma using spectral domain optical coherence tomography (SDOCT)
One eye each from 79 normal and 72 glaucoma patients were analyzed. All patients underwent a complete ophthalmological examination, including visual acuity testing; intraocular pressure, slit-lamp examination, indirect ophthalmoscopy; and the glaucoma group underwent achromatic perimetry with the 24-2 SITA FAST Humphrey Field Analyzer. All patients’ eyes were scanned using the SDOCT Spectralis and one of them was chosen randomly. Three consecutive circular B-scan centered at the optic disc were performed in one visit.
The ICC, COV and TRV for the mean RNFL thickness were respectively: 0.94, 2.56% and 4.85μm for the normal group and 0.93, 4.65% and 6.61μm for the glaucomatous group. The ICC for RNFL thickness in all quadrants were all excellent in both groups, with the superior quadrant having the highest ICCs (0.964) in glaucomatous eyes and nasal quadrant measurements having the lowest (0.800), but still excellent in eyes without glaucoma. The COV was between 2.56% - 8.74% and between 4.65% - 11.44% in normal and glaucomatous group respectively. The TRV was between 4.85μm and 11.51μm in the normal group and between 6.61μm and 14.24 μm in the glaucomatous group. Glaucomatous eyes were more variable than normal eyes.
Spectral domain OCT showed excellent reproducibility with regard to RNFL thickness measurements in patients without and with glaucoma.
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